Italian Auxological Institute
High blood pressure is the most common modifiable risk factor for cardiovascular diseases (CV). The large interindividual variability in clinical expression of the disease and response to treatment, however, makes the management of the hypertensive patient complex.Therefore, identifying phenotypes of hypertensive patients associated with a specific CV outcome or who tend to respond/not respond to treatment is of paramount importance for improving CV prevention. It has been shown that the phenotype of hypertensive patient with poor control of nighttime blood pressure values, especially when associated with a "non-dipper" profile, was associated with an increased risk of developing CV and cerebrovascular complications. The non-dipper profile and nocturnal hypertension are caused by several factors including excessive salt intake and dysautonomia. However, they are also inevitably influenced by sleep duration and the presence of sleep disorders: obstructive sleep apnea (OSA), but also insomnia and periodic movements of the lower limbs,such as those frequently seen in restless legs syndrome, are among the the main determinants related to altered nighttime pressure pattern. However, such disturbances are not systematically assessed during the performance of monitoring 24h pressor and their impact in the outcome of the hypertensive patient is unknown. The primary objective of this study is to phenotype non-dipper patients with or without nocturnal hypertension to determine the prevalence of sleep disorders such as sleep apnea syndrome, insomnia, and restless legs syndrome (RLS) (OSA diagnosed considering AHI\>5 events/hour, insomnia and RLS according to ICSD 3 criteria) and correlate the presence of various sleep disorders with cardiac organ damage, vascular, and renal damage mediated by hypertension.
Hypertension
Sleep Disorder
polysomnography
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 143 participants |
| Official Title : | PhenotypIsatioN of Sleep Pattern in hyperTensive Patients With blOod Pressure Non-DIPper Status |
| Actual Study Start Date : | 2023-05-04 |
| Estimated Primary Completion Date : | 2024-12-31 |
| Estimated Study Completion Date : | 2024-12-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
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RECRUITING
UOSD Arterial Hypertension "A.M. Pirrelli" - AOU Policlinico di Bari, University of Bari,
Bari, Italy, Bari, Italy, 70120
RECRUITING
Local Health Authority of the province of Brindisi
Toasts, Italy, Brindisi, Italy, 72100
RECRUITING
Internal Medicine 1, Hypertension and Metabolic Diseases Clinic AOU "Major of charity" - Novara
Novara, Italy, Novara, Italy, 28100
RECRUITING
Padua 1- Medical Clinic 3 · Department of Medicine · Hospital of Padua, Italy
Padua, Italy, Padova, Italy, 35128
RECRUITING
Padua 2 - UOC Emergency Medicine, Regional Center Specialized for Arterial Hypertension OSA - University of Padua Hospital, Italy
Padua, Italy, Padova, Italy, 35128
NOT YET RECRUITING
Cardiology Unit, Pneumology Unit, Cittadella Hospital, ULSS 6 Euganea Company, Cittadella, Italy.
Citadel, Italy, PD, Italy, 35013
NOT YET RECRUITING
Local Health Unit Company - IRCCS of Reggio Emilia - S.O.S Center for the Treatment of Arterial Hypertension - Cardiovascular Medicine II
Reggio Emilia, Italy, RE, Italy, 42122
NOT YET RECRUITING
Provincial Company for Health Services, Autonomous Province of Trento - Internal Medicine Unit - Rovereto
Rovereto, Italy, Trento, Italy, 38068
NOT YET RECRUITING
Giuliano-Isontina University Health Authority (ASU-GI)- SC (UCO) Clinical Medicine
Trieste, Italy, Trieste, Italy, 34128
RECRUITING
Department of Medicine, University of Verona, Verona, Italy
Verona, Italy, Verona, Italy, 37126
RECRUITING
Italian Auxological Institute IRCCS
Milan, MI, Italy, 20149