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NCT06302296 | RECRUITING | Tooth Mobility

Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement
Sponsor:

Hama University

Information provided by (Responsible Party):

FADI JNAID

Brief Summary:

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.

Condition or disease

Tooth Mobility

Injectable Platelet-rich Fibrin

Intervention/treatment

injectable form of PRF

Placebo injection

Phase

NA

Detailed Description:

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize. To this end, we set up this Randomized experiment to evaluate the effect of the injectable form of PRF (i-PRF) on OTM, using nonadditive containing i-PRF, which has higher levels of regenerative cells and growth factors compared with other PRF types because of the use of low centrifugation spee. Accordingly, we aimed to evaluate the effect of i-PRF on the rate of maxillary incisors leveling during comprehensive orthodontic treatment.

Study Type : INTERVENTIONAL
Estimated Enrollment : 14 participants
Masking : SINGLE
Primary Purpose : TREATMENT
Official Title : Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description
Actual Study Start Date : 2025-12-20
Estimated Primary Completion Date : 2026-05-15
Estimated Study Completion Date : 2026-07-15

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 26 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.
  • * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
  • * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
  • * The patient has good oral health.
Exclusion Criteria
  • * • The presence of any systemic disease that affects orthodontic dental movement.
  • * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
  • * The patient has undergone previous orthodontic treatment.
  • * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
  • * The patient has poor oral health.
  • * Commitment to periodic follow-up appointments.
Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement

Location Details

NCT06302296

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How to Participate

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Locations

RECRUITING

Syria,

Fadi Jnaid

Hama, Syria,