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NCT06296810 | RECRUITING | Parkinson Disease


Adaptive DBS to Offset STN Dysregulation During Exercise in PD
Sponsor:

University of Colorado, Denver

Brief Summary:

The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.

Condition or disease

Parkinson Disease

Intervention/treatment

aDBS

Detailed Description:

The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.

Study Type : OBSERVATIONAL
Estimated Enrollment : 10 participants
Official Title : Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease
Actual Study Start Date : 2024-09-01
Estimated Primary Completion Date : 2025-12
Estimated Study Completion Date : 2025-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 20 Years to 70 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.
  • \-
Exclusion Criteria
  • Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.

Adaptive DBS to Offset STN Dysregulation During Exercise in PD

Location Details

NCT06296810


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Locations


RECRUITING

United States, Colorado

University of Colorado

Aurora, Colorado, United States, 80045

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