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NCT06251310 | RECRUITING | Advanced Solid Tumor

SW-682 in Advanced Solid Tumors
Sponsor:

SpringWorks Therapeutics, Inc.

Brief Summary:

This is a first-in-human (FIH), Phase 1a/1b open-label, multicenter, dose escalation and dose expansion study of SW-682 in adult participants with metastatic or unresectable advanced solid tumors with or without Hippo pathway alterations that are refractory to, or have progressed, during or after appropriate prior systemic anticancer therapy, including chemotherapy, immunotherapy, radiation therapy or targeted therapy, or for which no treatment is available, or prior standard of care (SOC) therapy was not tolerated and for which there is no further SOC treatment available. The study includes a Part 1 (Phase 1a) dose escalation phase and a Part 2 (Phase 1b) dose expansion to optimize the dose to be used for further development. All participants will self-administer SW-682 by mouth in 28-day cycles.

Condition or disease

Advanced Solid Tumor

Mesothelioma, Malignant

Intervention/treatment

SW-682

Combination Therapy

Phase

PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 186 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 1a/1b Dose Escalation, Dose Expansion Study of SW-682 in Participants With Advanced Solid Tumors Enriched for Those With Hippo Pathway Mutations
Actual Study Start Date : 2024-07-30
Estimated Primary Completion Date : 2030-01
Estimated Study Completion Date : 2030-06

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Key Inclusion Criteria
  • * Histologically confirmed, metastatic, or unresectable solid cancer that has either not responded to or progressed during or after appropriate prior systemic anticancer therapy including chemotherapy, immunotherapy, radiation therapy, or appropriate targeted therapy, or for which there is no treatment available or prior SOC therapy was not tolerated and for which there is no further SOC treatment available
  • * Part 1: must have one of the following
    • * Mesothelioma with or without NF2 mutations
    • * Advanced solid tumors with NF2 mutations
    • * Advanced solid tumors with other Hippo pathway mutations or fusions (e.g., FAT1, LATS1/2, YAP fusions; WWTR1-CAMTA1 in EHE).
    • * Part 2: must have the tumor histology and oncogenic mutation or genomic aberration specific to each dose expansion cohort defined below
      • * Cohort 1: Participants with mesothelioma with or without NF2 mutations
      • * Cohort 2: Participants with advanced solid tumors with NF2 mutations
      • * Cohort 3: Participants with advanced solid tumors with other Hippo pathway mutations identified during Part 1 (Phase 1a) dose escalation
      • * Cohort 4: SW-682 with appropriate combination therapy.
      • * In both parts, participants should have known oncogenic mutation identified by Next Generation Sequencing or local assay
      • * Must have archival tumor tissue or agree to a fresh tumor biopsy at screening
      • * Measurable disease per RECIST 1.1
      • * Eastern Cooperative Oncology Group (ECOG) performance status of ≤1
      • * Adequate bone marrow, kidney, hepatic, and coagulation function
      • Key Exclusion Criteria
        • * Evidence of symptomatic CNS metastases, leptomeningeal carcinomatosis, or untreated spinal cord compression
        • * Clinically significant cardiac disease or abnormal cardiac parameters
        • * Preexistence or inheritance of a familial renal syndrome
        • * Concomitant non-anti-arrhythmic medications that are known to prolong the QTc interval
        • * Concomitant medicines that are known strong/moderate inhibitors or inducers of cytochrome P450 3A4 (CYP3A4) and/or CYP1A2 within 14 days or 5 half-lives before the first dose of study treatment
        • * Concomitant medicines that are known sensitive substrates of CYP3A4, CYP2C19, CYP2D6, CYP1A2, and/or CYP2B6 within 14 days or 5 half-lives before the first dose of study treatment
        • * Concomitant medicines that are known sensitive substrates of PGP, BCRP, OATP1B1, OATP1B3, OAT1, OAT3, MATE1, MATE2-K, OCT2
        • * Clinically significant active infection (bacterial, fungal, or viral)
SW-682 in Advanced Solid Tumors

Location Details

NCT06251310

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Arizona

SpringWorks Clinical Trial Site

Scottsdale, Arizona, United States, 85258

RECRUITING

United States, California

UC San Diego Moores Cancer Center

THE JOLLA, California, United States, 92093

RECRUITING

United States, California

USC/Norris Comprehensive Cancer Center

Los Angeles, California, United States, 90033

RECRUITING

United States, California

SpringWorks Clinical Trial Site

Los Angeles, California, United States, 90095

RECRUITING

United States, Ohio

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States, 44106

RECRUITING

United States, Oregon

Knight Cancer Institute Clinical Trials

Portland, Oregon, United States, 97239

RECRUITING

United States, Texas

Mary Crowley Cancer Research

Dallas, Texas, United States, 75230

RECRUITING

United States, Texas

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States, 77030