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NCT06230523 | ACTIVE NOT RECRUITING | Obesity

A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight
Sponsor:

Eli Lilly and Company

Brief Summary:

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with LY3841136 compared with placebo in adult participants with obesity or overweight. The study will last about 64 weeks and may include up to 17 visits.

Condition or disease

Obesity

Overweight and Obesity

Intervention/treatment

LY3841136

Placebo

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 250 participants
Masking : DOUBLE
Primary Purpose : TREATMENT
Official Title : A Phase 2, Parallel-Group, Double-Blind Study to Investigate Weight Management With LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight
Actual Study Start Date : 2024-02-05
Estimated Primary Completion Date : 2025-06
Estimated Study Completion Date : 2025-09

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • W8M-MC-LAA1
  • * Are males and females who agree to abide by the reproductive and contraceptive requirements
  • W8M-MC-CWMM
    • * Have a BMI ≥27 kg/m²
    • * Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss)
    Exclusion Criteria
    • W8M-MC-LAA1
    • * Have any prior diagnosis of diabetes mellitus except gestational diabetes.
    • * Have any of the following cardiovascular conditions within 6 months prior to screening
      • * acute myocardial infarction
      • * cerebrovascular accident (stroke)
      • * unstable angina, or
      • * hospitalization due to congestive heart failure (CHF).
      • * Have a history of acute or chronic pancreatitis.
      • * Have an on-going or history of bradyarrhythmia and/or sinus bradycardia at screening and baseline.
      • W8M-MC-CWMM
      • * Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
      • * Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
      • * Have poorly controlled hypertension.
      • * Have a history of symptomatic gallbladder disease within the past 2 years
      • * Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
      • * Have a lifetime history of suicide attempts.
A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight

Location Details

NCT06230523

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Arizona

The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Chandler, Arizona, United States, 85225

Not yet recruiting

United States, Arizona

Headlands Research - Scottsdale

Scottsdale, Arizona, United States, 85260

Not yet recruiting

United States, Arizona

The Institute for Liver Health II dba Arizona Liver Health-Tucson

Tucson, Arizona, United States, 85712

Not yet recruiting

United States, California

NorCal Medical Research, Inc

Greenbrae, California, United States, 94904

Not yet recruiting

United States, California

Velocity Clinical Research, Huntington Park

Huntington Park, California, United States, 90255

Not yet recruiting

United States, California

Peninsula Research Associates

Rolling Hills Estates, California, United States, 90274

Not yet recruiting

United States, California

Diablo Clinical Research, Inc.

Walnut Creek, California, United States, 94598

Not yet recruiting

United States, Florida

Northeast Research Institute (NERI)

Fleming Island, Florida, United States, 32003

Not yet recruiting

United States, Florida

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States, 34652

Not yet recruiting

United States, Florida

Charter Research - Winter Park

Orlando, Florida, United States, 32803

Not yet recruiting

United States, Florida

Charter Research - Lady Lake

The Villages, Florida, United States, 32162

Not yet recruiting

United States, Hawaii

Pacific Diabetes & Endocrine Center

Honolulu, Hawaii, United States, 96817

Not yet recruiting

United States, Idaho

Medical Research Partners

Ammon, Idaho, United States, 83406

Not yet recruiting

United States, Illinois

Great Lakes Clinical Trials - Andersonville

Chicago, Illinois, United States, 60640

Not yet recruiting

United States, Illinois

Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois, United States, 60640

Not yet recruiting

United States, Illinois

NorthShore University Health System

Skokie, Illinois, United States, 60077

Not yet recruiting

United States, Iowa

Iowa Diabetes and Endocrinology Research Center

West monks, Iowa, United States, 50265

Not yet recruiting

United States, Kansas

Cotton O'Neil Diabetes & Endocrinology

Stopy, Kansas, United States, 66606

Not yet recruiting

United States, Kentucky

L-MARC Research Center

Louisville, Kentucky, United States, 40213

Not yet recruiting

United States, Massachusetts

Knownwell

Needham, Massachusetts, United States, 02492

Not yet recruiting

United States, Massachusetts

Lucida Clinical Trials

New Bedford, Massachusetts, United States, 02740

Not yet recruiting

United States, Road cancer

Headlands Research - Detroit

Southfield, Road cancer, United States, 48034

Not yet recruiting

United States, Road cancer

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Road cancer, United States, 48098

Not yet recruiting

United States, Missouri

StudyMetrix Research

Saint Peters, Missouri, United States, 63303

Not yet recruiting

United States, Nevada

Las Vegas Medical Research

Las Vegas, Nevada, United States, 89128

Not yet recruiting

United States, New York

Dent Neurologic Institute

Amherst, New York, United States, 14226

Not yet recruiting

United States, New York

Velocity Clinical Research, Syracuse

East Syracuse, New York, United States, 13057

Not yet recruiting

United States, New York

North Suffolk Neurology

Port Jefferson Station, New York, United States, 11776

Not yet recruiting

United States, New York

Rochester Clinical Research, LLC

Rochester, New York, United States, 14609

Not yet recruiting

United States, North Carolina

Medication Management

Greensboro, North Carolina, United States, 27405

Not yet recruiting

United States, North Carolina

Monroe Biomedical Research

Monroe, North Carolina, United States, 28112

Not yet recruiting

United States, North Carolina

Lucas Research, Inc.

New Bern, North Carolina, United States, 28562

Not yet recruiting

United States, Ohio

CTI Clinical Research Center

Cincinnati, Ohio, United States, 45212

Not yet recruiting

United States, South Carolina

Tribe Clinical Research, LLC

Greenville, South Carolina, United States, 29607

Not yet recruiting

United States, Tennessee

Quality Medical Research

Nashville, Tennessee, United States, 37211

Not yet recruiting

United States, Texas

IMA Clinical Research Austin

Austin, Texas, United States, 78745

Not yet recruiting

United States, Texas

Velocity Clinical Research, Dallas

Dallas, Texas, United States, 75230

Not yet recruiting

United States, Texas

FutureSearch Trials of Dallas

Dallas, Texas, United States, 75251

Not yet recruiting

United States, Texas

Plan Research, PLLC

Houston, Texas, United States, 77079

Not yet recruiting

United States, Texas

Tekton Research - Fredericksburg Road

San Antonio, Texas, United States, 78229

Not yet recruiting

United States, Texas

Endeavor Clinical Trials

San Antonio, Texas, United States, 78240

Not yet recruiting

United States, Virginia

Spectrum Medical, Inc.

Danville, Virginia, United States, 24541

Not yet recruiting

United States, Washington

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington, United States, 98801

Not yet recruiting

Argentina, Autonomous City of Buenos Aires

Viamonte Medical Center

Buenos Aires, Autonomous City of Buenos Aires, Argentina, C1120AAC

Not yet recruiting

Argentina, Autonomous City of Buenos Aires

Medical Center Dr. Laura Maffei- Investigation Clinic Applied

Autonomous City of Buenos Aires, Autonomous City of Buenos Aires, Argentina, C1425AGC

Not yet recruiting

Argentina,

Metabolic Research Center (CINME)

Autonomous City of Buenos Aires, Argentina, C1056ABI