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NCT06217666 | NOT YET RECRUITING | Pancreatic Adenocarcinoma

Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients with Locally Advanced Pancreatic Adenocarcinoma (LAPC)
Sponsor:

ha o name (Carl) Q IU

Information provided by (Responsible Party):

ha o name (Carl) Q IU

Brief Summary:

The purpose of this study is to determine whether a new treatment combining radiation therapy with PCX12 is safe and tolerable.

Condition or disease

Pancreatic Adenocarcinoma

Intervention/treatment

PCX-12

Phase

PHASE1

Detailed Description:

Single center, open label, escalating dosage of PCX12 with standard of care practice for subjects who are diagnosed with adenocarcinoma of the head of the pancreas. Subjects with undergo standard of care radiation therapy and then start on PCX12 therapy starting at 200 ng/kg of PCX12 escalating to a potential maximum dosage of 800 ng/kg of PCX12 with adjacent tolerability and safety guidelines.

Study Type : INTERVENTIONAL
Estimated Enrollment : 24 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 1, Prospective, Standard Dose Escalation Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients with Locally Advanced Pancreatic Adenocarcinoma (LAPC)
Actual Study Start Date : 2025-06-01
Estimated Primary Completion Date : 2027-01-01
Estimated Study Completion Date : 2028-01-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Patient with pathologically proven diagnosis of adenocarcinoma of the pancreas
  • * Initially staged as locally advanced by National Comprehensive Cancer Network (NCCN) criteria of solid tumor contact with aorta, superior mesenteric artery (SMA) or celiac axis \>180 degrees and/or unreconstructable superior mesenteric vein/portal vein (SMV/PV) due to portal involvement or occlusion, tumor contact with most proximal draining jejunal branch into SMV
  • * Have completed first line chemotherapy without progression or non-regional metastases
  • * Tumor is radiographically evident on CT scan after chemotherapy
  • * Tumor is anatomically amenable to SBRT, e.g. does not directly invade the stomach or bowel
  • * Tumor is amenable to intra-tumor injection under endoscopic ultrasound guidance
  • * ECOG performance status 0-2
  • * Patients with childbearing potential must demonstrate a negative urine or serum pregnancy test
  • * Male or female subjects, aged at least 18 years; Female subjects of childbearing potential may participate if adequate contraception is used during, and for at least the three months after study completion; Male subjects with partners of childbearing potential may participate in the study if they had a vasectomy at least 6 months prior to randomization or if adequate contraception is used during, and for at least the three months after study completion; Adequate contraception is defined as resulting in a failure rate of less than 1% per year
  • * Patient must be able to understand and willingly sign study specific informed consent prior to study entry
  • * Anticipated life expectancy ≥ 12 weeks
  • * Patients aged at least 18 years of age
Exclusion Criteria
  • * Progression of disease or metastatic disease after first line systemic therapy
  • * Prior radiation treatment or surgical resection of any pancreatic malignancy
  • * Inability to tolerate SBRT, Endoscopic ultrasound or IL-12 Injection procedure
  • * Lack of radiographically evident disease after first line chemotherapy
  • * Severe, active comorbidity that shortens the patient's life expectancy to less than 12 weeks
  • * History of past malignancy
  • * Patient who is pregnant and/or breastfeeding
  • * Inability to comply with other required protocol procedures including required biopsies
Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients with Locally Advanced Pancreatic Adenocarcinoma (LAPC)

Location Details

NCT06217666

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How to Participate

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Locations

Not yet recruiting

United States, New York

University of Rochester

Rochester, New York, United States, 14642