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NCT06212791 | RECRUITING | Paroxysmal Atrial Fibrillation

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
Sponsor:

Virginia Commonwealth University

Brief Summary:

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Condition or disease

Paroxysmal Atrial Fibrillation

Intervention/treatment

Self- Report Evaluation-Duke Activity Status Index

Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

Cardiopulmonary exercise test (CPET)

Transthoracic echocardiogram

Ambulatory cardiac rhythm assessment

Cardiovascular magnetic resonance (CMR)

Detailed Description:

EXCLAMATORY is a longitudinal observational cohort clinical research study to evaluate the effects of catheter ablation for paroxysmal atrial fibrillation on left atrial and left ventricular performance during exercise, as well as effects on overall exercise capacity

Study Type : OBSERVATIONAL
Estimated Enrollment : 50 participants
Official Title : EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study
Actual Study Start Date : 2024-12-30
Estimated Primary Completion Date : 2028-03
Estimated Study Completion Date : 2028-03

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age ≥18 years
  • * Diagnosis of paroxysmal AF
  • * Left ventricular ejection fraction ≥50%
  • * Scheduled for catheter ablation
  • * Able to speak, hear, and read English
  • * Willing and able to provide informed consent
Exclusion Criteria
  • * Persistent or permanent AF
  • * Prior ablation (catheter based or surgical) for AF
  • * Significant sinus node dysfunction
  • * Implanted pacemaker or defibrillator
  • * Contraindication to or inability to complete cardiovascular magnetic resonance study
  • * Contraindication to or inability to complete exercise testing
  • * Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
  • * Severe left ventricular hypertrophy
  • * Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to
    • * Hypertrophic cardiomyopathy
    • * Cardiac amyloidosis
    • * Constrictive pericarditis
    • * Pulmonary arterial hypertension
    • * Prior cardiac surgery
    • * Active pregnancy
EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Location Details

NCT06212791

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How to Participate

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Locations

RECRUITING

United States, Virginia

Virginia Commonwealth University

Richmond, Virginia, United States, 23298