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NCT06158451 | NOT YET RECRUITING | Pain, Postoperative

Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR
Sponsor:

Cairo University

Information provided by (Responsible Party):

Sarah Khaled Latm

Brief Summary:

The aim of this study is to evaluate and compare the clinical effectiveness of zinc oxide-propolis mixture with triple antibiotic paste in LSTR as root canal filling material in necrotic primary molars.

Condition or disease

Pain, Postoperative

Periapical; Infection

Intervention/treatment

Zinc oxide propolis

Modified triple antibiotic paste

Phase

NA

Detailed Description:

The promising results of propolis as a natural antibiotic in previous in- vivo studies made it interesting to combine propolis to the golden standard zinc oxide eugenol as an intracanal medication in pulp affected primary molars and use this mix as a natural substitute to the modified triple antibiotic paste (m-TAP) and therefore overcoming the antibiotic bacterial resistance, allergy and developmental anomalies that might arise in permanent successor teeth from m-TAP usage.

Study Type : INTERVENTIONAL
Estimated Enrollment : 40 participants
Masking : DOUBLE
Masking Description : Double
Primary Purpose : TREATMENT
Official Title : Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in Lesion Sterilization and Tissue Repair (LSTR) for the Treatment of Necrotic Primary Molars: A Randomized Clinical Trial
Actual Study Start Date : 2024-03-01
Estimated Primary Completion Date : 2024-08-30
Estimated Study Completion Date : 2025-01-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 4 Years to 7 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Children
    • 1. Cooperative children aged 4 -7 years old.
    • 2. Systemically healthy.
    • * Teeth
      • Clinical criteria
        • 1. Necrotic primary mandibular second molar teeth.
        • 2. Spontaneous pain or tenderness to percussion
        • 3. Deep carious lesion with pulp exposure.
        • 4. Presence of chronic apical abscess or sinus tract Tooth should be restorable. (Thakur et al., 2021)
        • Radiographic criteria
          • 1. Coronal-radiographic evidence of a deep carious lesions or lesion approximating pulp
          • 2. Radicular discontinuity of lamina dura, furcation involvement less than or equal to half of shortest root in vertical dimension. (Thakur et al., 2021)
          Exclusion Criteria
          • * Children
            • 1. With physical or emotional alteration.
            • 2. Children with systemic disease.
            • 3. Previous history of allergy to antibiotics used in the study.
            • 4. Children that will not attend follow up. • Teeth
              • 1. Non restorable carious primary molars.
              • 2. Grade III mobility
Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR

Location Details

NCT06158451

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