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NCT06158061 | NOT YET RECRUITING | Acne Vulgaris

Assessment of Serum and Tissue Tryptase Levels in Acne Vulgaris Patients
Sponsor:

Sohag University

Information provided by (Responsible Party):

Mariam Magdy Mounir

Brief Summary:

Acne vulgaris is an inflammatory disorder of pilosebaceous glands. Acne is a highly prevalent inflammatory disease affecting approximately 9.4% of the world's population , and estimated up to 90% among adolescents. By natural course acne starts at 7-12 ages and mostly resolves by the third decade of individuals life . Mast cells may play important role in maintenance of physiological functions of our body; they also have a role in pathological and inflammatory mechanisms of many diseases. Tryptase is suggested to be important for survival as no tryptase-deficient human subject has yet been reported. Tryptase is mainly synthesized by mast cells but a very low amount may originate in basophil with no interference with total levels of the enzyme. Tryptase is currently considered as a metabolic signaling and effector mediator for acute mast cell degranulation and late phase of allergy and inflammation .

Condition or disease

Acne Vulgaris

Intervention/treatment

tryptase enzyme level

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 90 participants
Masking : NONE
Primary Purpose : DIAGNOSTIC
Official Title : Assessment of Serum and Tissue Tryptase Levels in Acne Vulgaris Patients
Actual Study Start Date : 2024-01-24
Estimated Primary Completion Date : 2024-08-15
Estimated Study Completion Date : 2024-08-15

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Patients with acne vulgaris ≥ 18 years old, both male and female patients will be included.
Exclusion Criteria
  • * Patients with the following criteria will be excluded from our study: 1- Pregnancy and breast feeding women. 2- Women on hormonal contraceptions. 3- Patients on topical/systemic treatment for AV during the last 6 months prior to the study. 4- Patients with other dermatological diseases e.g. psoriasis, vitiligo, DLE, etc. 5- Patients suffering from chronic medical illness such as; diabetes mellitus, thyroid disease, and cancer.
Assessment of Serum and Tissue Tryptase Levels in Acne Vulgaris Patients

Location Details

NCT06158061

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How to Participate

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Locations

Not yet recruiting

Egypt,

Sohag University Hospital

Sohag, Egypt,