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NCT06156241 | NOT YET RECRUITING | Post-Acute COVID-19 Syndrome

Stem Cell Study for Long COVID-19 Neurological Symptoms
Sponsor:

Charles Cox

Information provided by (Responsible Party):

Charles Cox

Brief Summary:

The purpose of this research study is to test the safety and benefit of a human cord blood derived stem cell infusion as a treatment for individuals with post COVID-19 neurological problems. Participants in the study will have 6 clinic visits over a 12 to 14 mo. period with each visit lasting 2 to 6 hours. Participants will receive 1 stem cell infusion at study visit #3. Participants will have a brain PET and MRI scan at the baseline and 6mo. post-infusion visits. Follow-up safety assessments will be conducted at 6mo. and 1yr. after the stem cell infusion.

Condition or disease

Post-Acute COVID-19 Syndrome

Intervention/treatment

Stem Cell

Phase

PHASE1

Detailed Description:

This is a non-randomized, Phase 1/2a dose escalation study using allogenic cord tissue MSC's in adults with chronic neurological symptoms following an acute COVID-19 infection.

Study Type : INTERVENTIONAL
Estimated Enrollment : 12 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Long COVID: Cord Tissue-Derived Mesenchymal Stromal Cells for Persistent NeuroInflammatory Symptoms
Actual Study Start Date : 2024-01
Estimated Primary Completion Date : 2025-12
Estimated Study Completion Date : 2026-02

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 55 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Adults between 18 and 55 years of age.
  • 2. Documented history of COVID-19 infection with resulting neurological sequela.
  • 3. Post-Covid-19 Functional Status score of grades 3 or 4.
  • 4. Chronic neurological symptoms defined as anxiety/depression, pain syndromes, sleep disorders, and /or memory disorders ("brain fog") persisting 6 months after an acute COVID-19 infection.
  • 5. Ability to obtain consent from the subject.
  • 6. Ability to communicate in English or Spanish (required for validated neurocognitive outcome testing).
Exclusion Criteria
  • 1. Known history of
    • 1. intellectual deficiency or psychiatric conditions likely to invalidate our ability to assess changes in cognition or behavior,
    • 2. recently treated infection,
    • 3. renal disease or altered renal function (screening serum creatinine \> 1.5 mg/dL),
    • 4. hepatic disease or altered liver function (screening SGPT \> 150 U/L and/or T. Bilirubin \>1.3 mg/dL),
    • 5. cancer,
    • 6. immunosuppression (screening WBC \< 3, 000 cells/ml),
    • 7. HIV+,
    • 8. chemical or ETOH dependency that in the opinion of the investigator would preclude participation in the study,
    • 9. acute or chronic lung disease requiring significant medication/oxygen supplementation,
    • 10. bleeding disorders including immune-mediated heparin-induced thrombocytopenia,
    • 11. hypercoagulable disorders (Protein C, S, ATIII deficiencies), Factor V Leiden,
    • 12. known sensitivity to heparin, Lovenox, and pork products,
    • 13. individuals with mechanical prosthetic heart valves.
    • 2. Pulse oximetry oxygen saturation \<93% on room air.
    • 3. Other acute or chronic medical conditions that, in the opinion of the investigator, may increase the risks associated with study participation.
    • 4. For women of childbearing potential, a positive pregnancy test at the screening visit or, for both women and men, unwillingness to comply with acceptable methods of birth control during the study.
    • 5. Previous or concurrent participation in an interventional drug or biological study.
    • 6. Inability to undergo the diagnostic tests (PET/DT-MRI) or unwilling/unable to cooperate with the diagnostic tests and outcome assessments.
    • 7. Unwilling or unable to return for follow-up study visits.
    • 8. Prisoner/Incarcerated.
Stem Cell Study for Long COVID-19 Neurological Symptoms

Location Details

NCT06156241

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Texas

The University of Texas Health Science Center at Houston

Houston, Texas, United States, 77030