University Hospital, Limoges
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS. Participants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.
Amyotrophic Lateral Sclerosis
Blood sample
NA
ALS is the most frequent adult onset motor neuron disease and is highly variable in terms of clinical features, genetics, and neuropathology. A large body of evidence has demonstrated the importance of weight loss at the time of diagnosis and during disease progression. Weight loss affects between one and two-thirds of patients and is adversely associated with survival. High caloric nutrition was able to slow weight loss and prolong survival in fast progressing ALS patients. Pathophysiological mechanisms underlying weight loss remain unknown because high-quality cohort data collecting clinical features, genetics, omics, and imaging related to the metabolic and disease status of patients are lacking. The investigators hypothesize that weight loss in ALS patients is biologically driven through specific pathways. The investigators propose an innovative and ambitious multidisciplinary project to structure a large French-German cohort to identify markers associated with weight loss. The investigators aim at identifying the biological correlates of weight loss to disentangle the mechanistic basis of this critical symptom and to determine clinical and biological profiles along with their impact on disease progression and survival.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1000 participants |
| Masking : | NONE |
| Primary Purpose : | OTHER |
| Official Title : | French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis |
| Actual Study Start Date : | 2024-09-17 |
| Estimated Primary Completion Date : | 2027-09-30 |
| Estimated Study Completion Date : | 2029-09-30 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
NOT YET RECRUITING
chu's Lille
Lille, France, 59037
RECRUITING
Limoges University Hospital
Limoges, France, 87042
NOT YET RECRUITING
Timone Hospital
Marseille, France, 13005
NOT YET RECRUITING
Gui Chauliac Hospital
Montpellier, France, 34295
NOT YET RECRUITING
chu's nice
Nice, France, 06001
NOT YET RECRUITING
Pitié Salpêtrière Hospital
Paris, France, 75013
NOT YET RECRUITING
Chu's tours
Tours, France, 37044