Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06144476 | RECRUITING | COPD

Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
Sponsor:

Guy's and St Thomas' NHS Foundation Trust

Brief Summary:

There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.

Condition or disease

COPD

Asthma

Airway Disease

Detailed Description:

In this observational study, we will be enrolling patients with diagnosed or suspected airways disease who are over 18 years old, as well as age matched healthy volunteers with no significant illness. Participants will be asked if they consent to enter the study, invited at clinically relevant time points (treatment change, disease exacerbation etc.) and to optional bronchoscopy visits. It is expected that participants will be seen yearly with any additional exacerbation/treatment visits also recorded. Research visits will occur at King's College London and the Guys and St Thomas' NHS Foundation Trust (GSTFT), with all bronchoscopy visits occurring within GSTFT 1. Disease specific questionnaires. 2. Lung function tests including spirometry or oscillometry (if not performed previously within 6 months) 3. Sputum collection 4. Nasal sampling including nasosorption, nasal brushing, nasal lavage, or nasopharyngeal swabs 5. Exhaled breath 6. Blood samples (\<6 tablespoons) Optional 7. Bronchoscopy involving a flexible fibreoptic camera passed into the lungs to collect bronchoalveolar lavage, bronchosorption, bronchial brushings and bronchial biopsies. 8. To repeat these procedures at later time - expected once per year or at times of clinically relevant changes

Study Type : OBSERVATIONAL
Estimated Enrollment : 230 participants
Official Title : Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
Actual Study Start Date : 2024-02-08
Estimated Primary Completion Date : 2026-08-31
Estimated Study Completion Date : 2029-08-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Participant is willing and able to give informed consent for participation in the study
  • * Aged 18 years or above
  • * Patient: known or suspected airway disease
  • * Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.)
Exclusion Criteria
  • * Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
  • * Surgery within the preceding 6 weeks
  • * Participants who are pregnant
  • * History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection
  • * Alcohol or recreational drug abuse
  • * Diagnosis of immunodeficiency requiring treatment
  • * Unable to provide written informed consent
  • * Unable to read or write English
  • * Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

Location Details

NCT06144476

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United Kingdom,

Guy's & St Thomas' NHS Foundation Trust

London, United Kingdom, SE1 9RT