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NCT06044051 | RECRUITING | Asthma in Children

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma
Sponsor:

University Hospital, Rouen

Brief Summary:

Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment. Exploring and understanding these data is to improve patient care and discover new therapeutic targets. The aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.

Condition or disease

Asthma in Children

Asthma

Intervention/treatment

Blood sample

Expectoration

Nasopharyngeal swab

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 100 participants
Masking : NONE
Primary Purpose : PREVENTION
Official Title : Dynamics of upper and lower respiratory microbiomes associated with severe asthma in infants
Actual Study Start Date : 2023-09-26
Estimated Primary Completion Date : 2026-09-26
Estimated Study Completion Date : 2026-09-26

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: to 24 Months
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Infants less than 24 months old
  • * Follow-up by a pneumo-pediatrician for severe asthma in infants
  • * Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)
  • * Parent informed of the research and having signed consent
Exclusion Criteria
  • * Prematurity \<32 WA
  • * Congenital heart disease with significant left to right shunt
  • * Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)
  • * Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)
  • * Refusal of bronchial fibroscopy
Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma

Location Details

NCT06044051

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Locations

RECRUITING

France,

Rouen University Hospital

Rouen, France,