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NCT05999994 | RECRUITING | Neoplasms

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
Sponsor:

Eli Lilly and Company

Brief Summary:

The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New studies will be added as new drugs emerge against different cancers. Participation in the trial will depend on how long the benefit lasts.

Condition or disease

Neoplasms

Child

Adolescent

Intervention/treatment

Ramucirumab

Cyclophosphamide

Vinorelbine

Gemcitabine

Docetaxel

Abemaciclib

Irinotecan

Temozolomide

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 105 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : CAMPFIRE: Children's and Young Adult Master Protocol for Innovative Pediatric Research
Actual Study Start Date : 2020-01-22
Estimated Primary Completion Date : 2027-05
Estimated Study Completion Date : 2027-05

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 1 Year to 39 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • Participants must meet all of the inclusion criteria below. Additional criteria are specified in the protocol amendment (individual addenda) to which the participant will enroll.
  • * Have either measurable or evaluable disease using standard techniques by the Response Evaluation Criteria in Solid Tumors, Version 1.1 (RECIST 1.1).
  • * The participant has a Lansky (\<16 years of age) or Karnofsky (≥16 years of age) performance score of at least 50.
  • * Participants must have discontinued all previous treatments for cancer or investigational agents greater than or equal to (≥)7 days after the last dose and must have recovered from clinically significant side effects.
  • * The participant has adequate hematologic and organ function.
  • * Female participants of childbearing potential must have a negative urine or serum pregnancy test within 7 days prior to first dose.
  • * Both female and male participants of childbearing potential must agree to use highly effective contraceptive precautions during the trial and for at least 3 months following the last dose of study drug.
  • Participants will be ineligible if they meet any of the exclusion criteria below. Additional criteria are specified in the protocol amendment to which the participant will enroll.
  • * Participants with severe and/or uncontrolled concurrent medical disease or psychiatric illness/social situation that, in the opinion of the investigator, could cause unacceptable safety risks or compromise compliance with the protocol.
  • * Participants who have active infections requiring therapy.
  • * Participants who have had allogeneic bone marrow or solid organ transplant.
  • * Participants who have had, or are planning to have, certain invasive procedures.
  • * Female participants who are pregnant or breastfeeding.
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

Location Details

NCT05999994

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

NOT YET RECRUITING

United States, Albama

Childrens Hospital of Alabama

Birmingham, Albama, United States, 35233

RECRUITING

United States, Arizona

Phoenix Children's Hospital

Phoenix, Arizona, United States, 85016

COMPLETED

United States, California

Childrens Hospital of Los Angeles

Los Angeles, California, United States, 90027

NOT YET RECRUITING

United States, California

UCLA Medical Center

Los Angeles, California, United States, 90095

RECRUITING

United States, California

Children's Hospital of Orange County

Orange, California, United States, 92868

RECRUITING

United States, Colorado

Children's Hospital of Colorado

Denver, Colorado, United States, 80218

RECRUITING

United States, District of Columbia

Children's National Medical Center

Washington, District of Columbia, United States, 20010

RECRUITING

United States, Florida

Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, United States, 33908

RECRUITING

United States, Florida

Mayo Clinic in Florida

Jacksonville, Florida, United States, 32224

NOT YET RECRUITING

United States, Georgia

Children's Healthcare of Atlanta, Inc. at Egleston

Atlanta, Georgia, United States, 30322

RECRUITING

United States, Illinois

Ann & Robert H Lurie Children's Hospital of Chicago

Chicago, Illinois, United States, 60611

ACTIVE NOT RECRUITING

United States, Indiana

Riley Hospital for Children

Indianapolis, Indiana, United States, 46202-5225

NOT YET RECRUITING

United States, Massachusetts

Dana-Farber Cancer Institute

Boston, Massachusetts, United States, 02215

NOT YET RECRUITING

United States, Road cancer

C.S. Mott Children's Hospital

Ann Arbor, Road cancer, United States, 48109

NOT YET RECRUITING

United States, Minnesota

University of Minnesota Hospital

Minneapolis, Minnesota, United States, 55455

RECRUITING

United States, Missouri

Children's Mercy Hospital

Kansas City, Missouri, United States, 64108

ACTIVE NOT RECRUITING

United States, Missouri

Washington University Medical School

Saint Louis, Missouri, United States, 63110

RECRUITING

United States, New York

Memorial Sloan Kettering Cancer Center

New York, New York, United States, 10065

RECRUITING

United States, Ohio

Nationwide Children's Hosp

Columbus, Ohio, United States, 43205-2664

NOT YET RECRUITING

United States, Oregon

Oregon Health and Science University

Portland, Oregon, United States, 97201

COMPLETED

United States, Pennsylvania

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

RECRUITING

United States, Pennsylvania

UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States, 15224

RECRUITING

United States, Rhode Island

Lifespan Cancer Institute

Providence, Rhode Island, United States, 02906

RECRUITING

United States, Texas

University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, United States, 75390-9063

ACTIVE NOT RECRUITING

United States, Texas

Cook Children's Hospital

Fort Worth, Texas, United States, 76104-2724

NOT YET RECRUITING

United States, Texas

Texas Childrens Hospital

Houston, Texas, United States, 77025

RECRUITING

United States, Texas

University of Texas MD Anderson Cancer Center

Houston, Texas, United States, 77030

RECRUITING

United States, Washington

Seattle Children's Hospital Research Foundation

Seattle, Washington, United States, 98105

NOT YET RECRUITING

United States, Wisconsin

Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

RECRUITING

Australia, New South Wales

Chris O'Brien Lifehouse

Camperdown, New South Wales, Australia, 2050

NOT YET RECRUITING

Australia, New South Wales

The Sydney Children's Hospitals Network

Westmead, New South Wales, Australia, 2145

RECRUITING

Australia, Victoria

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia, 3000

RECRUITING

Australia, Victoria

Royal Children's Hospital

Melbourne, Victoria, Australia, 3052

COMPLETED

Belgium, East Flanders

University Hospital Ghent

Gent, East Flanders, Belgium, 9000

RECRUITING

Belgium,

UCL- Saint Luc

Bruxelles, Belgium, 1200

RECRUITING

France, Aquitaine

Bergonié Institute - Regional Center for the Fight against Bordeaux and South West cancer

Bordeaux, Aquitaine, France, 33076

NOT YET RECRUITING

France, Rhône-Alpes

Center Leon Berard

Lyon, Rhône-Alpes, France, 69008

RECRUITING

France, Rhône-Alpes

Center Leon Berard

Lyon, Rhône-Alpes, France, 69008

NOT YET RECRUITING

France,

Curie Institute

Paris, France, 75248

RECRUITING

Germany, Baden-Württemberg

Universitaetsklinikum Freiburg

Freiburg, Baden-Württemberg, Germany, 79106

RECRUITING

Germany,

University Clinic Essen

Essen, Germany, 45147

RECRUITING

Germany,

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany, 20251

RECRUITING

Italy, Lombardy

National Cancer Institute

Milano, Lombardy, Italy, 20133

RECRUITING

Italy, Milano

Humanitas Clinical Institute

Rozzano, Milano, Italy, 20089

RECRUITING

Italy, Torino

Institute of Candiolo IRCCS - Piedmont Foundation for Oncology

Cadlo, Torino, Italy, 10060

RECRUITING

Italy, Veneto

Hospital of Padua

Padova, Veneto, Italy, 35128

RECRUITING

Italy,

IRCCS Rizzoli Orthopedic Institute

Bologna, Italy, 40136

RECRUITING

Italy,

Gesu Child Hospital

Roma, Italy, 00165

RECRUITING

Italy,

Agostino Gemelli IRCCS University Polyclinic Foundation - Catholic University of the Sacred Heart

Roma, Italy, 00168

RECRUITING

Japan, Hyogo

Hyogo Prefectural Kobe Children's Hospital

Kobe, Hyogo, Japan, 650-0047

RECRUITING

Japan, Tokyo

National Cancer Center Hospital

C-Cry, Tokyo, Japan, 104-0045

RECRUITING

Japan,

Kyushu University Hospital

Fukuoka, Japan, 812-8582

RECRUITING

Netherlands, South Holland

Leiden University Medical Center

Leiden, South Holland, Netherlands, 2333 for

RECRUITING

Netherlands,

Princess Maxima Center

Utrecht, Netherlands, 3584 CS

RECRUITING

Spain, Barcelona [Barcelona]

Vall d'Hebron University Hospital

Barcelona, Barcelona [Barcelona], Spain, 8035

RECRUITING

Spain, Barcelona [Barcelona]

Vall d'Hebron University Hospital

Barcelona, Barcelona [Barcelona], Spain, 8035

RECRUITING

Spain, Barcelona [Barcelona]

Hospital Sant Joan de Déu

Esplugues de Llobregat, Barcelona [Barcelona], Spain, 8950

RECRUITING

Spain, Madrid, community of

Niño Jesús University Children's Hospital

Madrid, Madrid, community of, Spain, 28009

RECRUITING

Spain, Santa Cruz de Tenerife

Canary Islands University Hospital

The lagoon, Santa Cruz de Tenerife, Spain, 38320

RECRUITING

Spain,

Hospital of the Holy Cross and Sant Pau

Barcelona, Spain, 08025

RECRUITING

Spain,

Gregorio Marañon University General Hospital

Madrid, Spain, 28007

RECRUITING

Spain,

Gregorio Marañon University General Hospital

Madrid, Spain, 28007

RECRUITING

Spain,

La Paz University Hospital

Madrid, Spain, 28046

RECRUITING

Spain,

La Paz University Hospital

Madrid, Spain, 28046

RECRUITING

Spain,

Virgen del Rocio University Hospital

Sevilla, Spain, 41013

RECRUITING

Spain,

Virgen del Rocio University Hospital

Sevilla, Spain, 41013

RECRUITING

Spain,

Hospital University the Policenics The F

Valencia, Spain, 46026

RECRUITING

United Kingdom, Greater London

University College Hospital - London

London, Greater London, United Kingdom, Nw1 2bu

RECRUITING

United Kingdom,

Royal Marsden Hospital

London, United Kingdom, Jaya Taj

RECRUITING

United Kingdom,

Royal Marsden Hospital

London, United Kingdom, Jaya Taj

RECRUITING

United Kingdom,

Royal Manchester Children's Hospital

Manchester, United Kingdom, M 139 and l

RECRUITING

United Kingdom,

The Christie NHS Foundation Trust

Manchester, United Kingdom, M20 4BX