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NCT05877274 | Recruiting | Anterior Cutaneous Nerve Entrapment Syndrome

Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
Sponsor:

Maxima Medical Center

Information provided by (Responsible Party):

Dr. RMH Roumen, surgeon

Brief Summary:

The goal of this observational study is to learn about sodium channel (Nav) mutations in patients with the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). This study will give more insight into the pathophysiology of ACNES, which is still largely unknown. The primary objective is to determine if there are mutations of Nav1.7 and Nav1.8 in patients with ACNES. Therefore, one blood sample will be drawn, in which the mutations will be analyzed.

Condition or disease

Anterior Cutaneous Nerve Entrapment Syndrome

Nerve Entrapment Syndrome

Chronic Pain Syndrome

Intervention/treatment

Sodium channel mutation

Study Type : Observational
Estimated Enrollment : 50 participants
Official Title : Sodium Channel Mutations (SCN9A, SCN10A) in the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
Actual Study Start Date : October 3, 2023
Estimated Primary Completion Date : June 2024
Estimated Study Completion Date : December 2024

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • In order to be eligible to participate in this study, a subject must be diagnosed with ACNES and receive treatment at our outpatient clinic. Additionally, subject has to meet one of the following criteria
    • Known to have a first- or second-degree relative with ACNES;
    • Have more than one recurrence of ACNES after a pain free period or ACNES at multiple locations in the abdominal wall;
    • Persistent pain after posterior neurectomy.
    Exclusion Criteria
    • Inability to understand Dutch language.
    • Known neuromuscular or neurodegenerative disease.
Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

Location Details

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Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Recruiting

Netherlands,

Maxima Medical Center

Veldhoven, Netherlands, 5504 DB