University of Cologne
Prof. Dr. Paul Brinkkoetter
The interpretation of platelet counts has to be revaluated in the light of caplacizumab. By effectively blocking platelet binding sites on VWF-multimers, the nanobody leads to a rapid normalization of the platelet count within 3 to 4 days. Most importantly, caplacizumab uncouples platelet counts from ADAMTS13 activity and thereby launches unprecedented thrombocyte dynamics, with potential pitfalls for over- and undertreatment. A relevant number of patients responds to caplacizumab with a brisk increase in platelet count, followed by a marked dip of platelets (patient on the left). This may mislead treating physicians into re-intensifying therapy, with a respective risk for adverse side-effects and complications. Taken together, these observations call for reliable descriptions and the identification of predictive parameters to predict the platelet response upon administration of caplacizumab in a large patient cohort. Here, PREDICT-2020 is designed as a retrospective study to specifically address the following aspects: * Identifying and describing clusters of platelet responses to caplacizumab * Identifying potential pitfalls for treating physicians * Predicting the individual thrombocyte response * Correlating platelet responses with individual patient outcome
Acquired Thrombotic Thrombocytopenic Purpura
Cablivi
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 160 participants |
| Official Title : | Platelet Response to Caplacizumab in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura |
| Actual Study Start Date : | 2023-10-30 |
| Estimated Primary Completion Date : | 2025-03-30 |
| Estimated Study Completion Date : | 2025-03-30 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University Hospital of Cologne
Cologne, Germany,