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NCT05875636 | COMPLETED | Gastric Content Aspiration

GLP-1 Receptor Agonist Use and Incidence of Retained Gastric Food on Endoscopy
Sponsor:

Medical University of South Carolina

Information provided by (Responsible Party):

Phillip Wilson

Brief Summary:

This study will enroll patients ages 18 and over who are in one of the following groups 1) taking a GLP-1 receptor agonist medication 2) not taking a GLP-1 receptor agonist (control group), are undergoing EGS and have appropriately fasted. Study data will be collected in the form of qualitatively observing whether the stomach is empty as expected, or contains solid or clinically relevant liquid contents.

Condition or disease

Gastric Content Aspiration

Intervention/treatment

Esophagogastroduodenoscopy

Study Type : OBSERVATIONAL
Estimated Enrollment : 260 participants
Official Title : GLP-1 Receptor Agonist Use and Incidence of Retained Gastric Food on Endoscopy
Actual Study Start Date : 2023-08-21
Estimated Primary Completion Date : 2024-08-23
Estimated Study Completion Date : 2024-08-23

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Adults 18 years of age and older presenting for esophagogastroduodenoscopy (EGD)
  • * One of the following groups
    • * GLP-1 receptor agonist cohort: active treatment with any GLP-1 receptor agonist therapy within prior 30 days
    • * Control cohort: not taking a GLP-1 receptor agonist medication
    • * Appropriately fasted per ASA Fasting Guidelines
    Exclusion Criteria
  • * Simultaneous bowel preparation/planned dual endoscopy with colonoscopy
  • * Any pre-planned alteration to standard fasting guidelines (ASA NPO guidelines)
  • * Emergency endoscopic procedure
  • * Concern for active GI bleeding
  • * Food impaction/foreign body as indication for procedure
  • * Gastric outlet obstruction/bowel obstruction
  • * Achalasia
  • * Zenker's diverticulum
  • * History of esophageal or gastric surgery
  • * Active pregnancy
  • * Chronic daily opioid therapy ≥ 15 MMEs per day
  • * Prokinetic agent use (i.e. metoclopramide)
  • * Inability or unwillingness of subject to give informed consent
    • GLP-1 Receptor Agonist Use and Incidence of Retained Gastric Food on Endoscopy

    Location Details

    NCT05875636

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    How to Participate

    Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

    Locations

    Not yet recruiting

    United States, South Carolina

    Medical University of South Carolina

    Charleston, South Carolina, United States, 29424