Thinking of joining a study?

Register your interest

NCT05867108 | Recruiting | Prosthesis Related Infection


Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study
Sponsor:

University Hospital, Strasbourg, France

Brief Summary:

Studies on sonication suffer from a heterogeneity which makes their analysis complex, due to the absence of a gold standard allowing positive cases to be defined unequivocally. Thus, the sensitivity of the technique has been assessed on cases defined in different ways, which makes the studies difficult to compare (number of samples taken, number of positive samples, variable duration of culture, etc.). It should nevertheless be noted that the majority of the series conclude with a higher sensitivity than that of standard samples, in particular in the event of a strain with difficult growth (Cutibacterium acnes, deficient Streptococci) or in the event of prior antibiotic therapy. In the absence of a comparative reference allowing to conclude on the intrinsic performances of sonication as a diagnostic test, it seems interesting to evaluate its contribution in current practice, in particular in the difficult cases where the standard culture does not make it possible to fulfill the criterion. major (zero or only one positive sample). To the knowledge of the investigators, there is no study of this kind, which could make it possible to specify the place of this technique in the diagnostic procedure and to improve the care of patients.

Condition or disease

Prosthesis Related Infection

Study Type : Observational
Estimated Enrollment : 200 participants
Official Title : Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: Retrospective Cohort Study From 2019 to 2022 at the University Hospitals of Strasbourg
Actual Study Start Date : June 1, 2023
Estimated Primary Completion Date : March 3, 2024
Estimated Study Completion Date : March 3, 2024

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Criteria
Inclusion criteria
  • Adult patients (age ≥18 years)
  • Have been hospitalized and operated on for a change of hip or knee joint prosthesis between 01/01/2019 and 07/31/2022
  • Have had at least 3 samples taken for microbiological purposes, pre- or intraoperatively
  • the explanted prosthesis must have been analyzed by sonication.
  • not opposing the reuse of its data for scientific research purposes
  • Exclusion criteria
    • - Opposition of the patient to the reuse of his data.

Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study

Location Details


Please Choose a site



Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Recruiting

France,

Orthopedic Septic Surgery department - Strasbourg University Hospital - France

Strasbourg, France, 67091

Loading...