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NCT05864794 | Not yet recruiting | Non Small Cell Lung Cancer Metastatic

Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer
Sponsor:

University Medical Center Groningen

Brief Summary:

Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease will undergo an MRI of the brain to screen for brain disease.

Condition or disease

Non Small Cell Lung Cancer Metastatic

Intervention/treatment

MRI

Phase

Not Applicable

Study Type : Interventional
Estimated Enrollment : 100 participants
Masking : None (Open Label)
Primary Purpose : Screening
Official Title : ValUe of Screening MRI Brain in Patients With Newly Diagnosed Stage IV Non-oncogene Addicted Non-small Cell Lung CANcer - The VULCAN Trial
Actual Study Start Date : January 1, 2024
Estimated Primary Completion Date : September 1, 2025
Estimated Study Completion Date : December 31, 2025
Arm Intervention/treatment

Experimental: Screening population

Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease.

Diagnostic Test: MRI
Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Histologically or cytologically confirmed stage IV metastatic NSCLC, not amenable to curative treatment.
  • Fit for systemic treatment (PS 0-2) according to standard of care.
  • No symptoms of brain disease disease assessed according to standard clinical care by the thoracic oncologist.
Exclusion Criteria
  • Prior/concomitant therapy for stage IV disease.
  • Oncogenic diver mutation (e.g. EGFR, ALK, ROS1, RET, MET, and BRAF) with approved targeted treatment.
  • Contraindications for MRI scan with contrast as per standard of care protocol of the institution.
Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer

Location Details

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Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer

How to Participate

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