University of Pennsylvania
The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.
Obesity
Interstitial Lung Disease
Chronic Obstructive Pulmonary Disease
Sarcoidosis, Pulmonary
Pulmonary Hypertension
Semaglutide Pen Injector
PHASE1
PHASE2
This is a small open-label pilot clinical trial of semaglutide in adults (age 18 or older, n=8) with obesity (BMI≥30 kg/m2), and chronic advanced lung disease (interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension requiring supplemental oxygen on exertion). This study will evaluate medication adherence and side effects to determine semaglutide tolerability. Markers of physical function and pulmonary function will be evaluated before therapy and after 12 weeks of therapy to determine the effect of semaglutide on function. Measures of fat and muscle, will be performed before therapy and after 12 weeks of therapy to evaluate how semaglutide alters body composition in this population. Study participants will be monitored for 12 weeks while receiving semaglutide therapy.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 8 participants |
| Masking : | NONE |
| Primary Purpose : | TREATMENT |
| Official Title : | Feasibility of Semaglutide Therapy for Weight Loss in Advanced Lung Disease: A Pilot Study |
| Actual Study Start Date : | 2024-01-29 |
| Estimated Primary Completion Date : | 2025-12-28 |
| Estimated Study Completion Date : | 2025-12-28 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years to 80 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104