IRCCS Policlinico S. Donato
Alessandro Pini
The goal of this observational study is to study arterial stiffness in patients with ascending aortic aneurysms, either syndromic or non syndromic. The main questions it aims to answer are: Stratification of aortic risk based on Pulse Wave Velocity; Compare measurements with morphological and hemodynamic features of the ascending thoracic aorta. Participants will be asked to undergo non invasive evaluation of blood pressure and arterial pulse wave velocity.
Rare Diseases
Aortic Stiffness
Connective Tissue Defect
Pulsotonometry
Recent studies have highlighted the role played by the aorta and the great arteries in the regulation of the blood pressure (BP) and peripheral blood flow. Similarly, the structural and functional alteration of the aortic wall having a genetic cause is highly associated with the onset of aneurysms, especially of the ascending aorta, for which it is essential to monitor the aortic stiffness, which is detectable through a non-invasive and non-radioactive method such as Pulse Wave Velocity (PWV). Despite literature studies correlating PWV in MFS, few evaluations of aortic stiffness in patients with syndromic TAA have been done and its potential correlations with other aneurysm markers.}}
| Study Type : | Observational |
| Estimated Enrollment : | 250 participants |
| Official Title : | Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis |
| Actual Study Start Date : | February 15, 2023 |
| Estimated Primary Completion Date : | February 2024 |
| Estimated Study Completion Date : | September 2024 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | |
| Sexes Eligible for Study: | All |
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Recruiting
IRCCS Policlinico San Donato
San Donato Milanese, Lombardy, Italy, 20097