IRCCS Polyclinic San. Donate
Alessandro Pini
The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are: * Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta. Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.
Rare Diseases
Aortic Stiffness
Connective Tissue Defect
Pulsotonometry
Recent studies have highlighted the role played by the aorta and the great arteries in the regulation of the blood pressure (BP) and peripheral blood flow. Similarly, the structural and functional alteration of the aortic wall having a genetic cause is highly associated with the onset of aneurysms, especially of the ascending aorta, for which it is essential to monitor the aortic stiffness, which is detectable through a non-invasive and non-radioactive method such as Pulse Wave Velocity (PWV). Despite literature studies correlating PWV in MFS, few evaluations of aortic stiffness in patients with syndromic TAA have been done and its potential correlations with other aneurysm markers.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 250 participants |
| Official Title : | Aortic Stiffness in Patients with Genetic Aortopathies: Intervention Analysis |
| Actual Study Start Date : | 2023-02-15 |
| Estimated Primary Completion Date : | 2025-06-30 |
| Estimated Study Completion Date : | 2025-12-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
IRCCS Polyclinic San Donato
San Donato Milanese, Lombardy, Italy, 20097