West Virginia University
Jessica Frey
This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.
Tourette Syndrome
transcranial magnetic stimulation
Not Applicable
| Study Type : | Interventional |
| Estimated Enrollment : | 20 participants |
| Masking : | Double |
| Primary Purpose : | Treatment |
| Official Title : | Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study |
| Actual Study Start Date : | March 12, 2024 |
| Estimated Primary Completion Date : | March 30, 2025 |
| Estimated Study Completion Date : | December 30, 2025 |
| Arm | Intervention/treatment |
|---|---|
|
Active Comparator: Active rTMS Patients receiving active rTMS |
Device: transcranial magnetic stimulation |
|
Sham Comparator: Sham rTMS Patients receiving sham rTMS |
Device: transcranial magnetic stimulation |
| Ages Eligible for Study: | 18 Years to 100 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
WVU RNI
Morgantown, West Virginia, United States, 26506