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NCT05648565 | COMPLETED | Chronic Rhinitis

Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis
Sponsor:

The University of Texas Health Science Center, Houston

Information provided by (Responsible Party):

David Z. Allen

Brief Summary:

The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure.

Condition or disease

Chronic Rhinitis

Intervention/treatment

Radiofrequency ablation (RFA)

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 17 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis
Actual Study Start Date : 2023-01-10
Estimated Primary Completion Date : 2024-02-20
Estimated Study Completion Date : 2024-02-20

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 80 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasal drip)
  • * poor response to medical management that was attempted for at least 4 weeks
  • * a rTNSS score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion.
Exclusion Criteria
  • * active sinusitis
  • * rhinitis medicamentosa
  • * recurrent and ongoing epistaxis
  • * immunodeficiency as defined by an illness or a history of sinus surgery.
Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis

Location Details

NCT05648565

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How to Participate

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Locations

Not yet recruiting

United States, Texas

The University of Texas Health Science Center at Houston

Houston, Texas, United States, 77030