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NCT05641766 | NOT YET RECRUITING | THC

Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
Sponsor:

Yale University

Information provided by (Responsible Party):

Jose Cortes

Brief Summary:

The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.

Condition or disease

THC

Intervention/treatment

THC

Placebo

Phase

PHASE2

Detailed Description:

The goal of this study is to use multimodal MEG/EEG to gain novel insight into the acute effects of THC on neural noise and its interaction with the fast information processing dynamics of the brain's cognition-related functional neural networks.

Study Type : INTERVENTIONAL
Estimated Enrollment : 50 participants
Masking : DOUBLE
Primary Purpose : OTHER
Official Title : Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
Actual Study Start Date : 2024-12-31
Estimated Primary Completion Date : 2025-12-01
Estimated Study Completion Date : 2025-12-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 21 Years to 65 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Cannabis use at least once in the past 12 months
  • * No cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test day
  • * Good physical and mental health
Exclusion Criteria
  • * Cannabis naïve individuals
  • * Lifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion.
  • * Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completion
  • * Major current or recent stressors
  • * Positive urine drug test
  • * Contraindication for Magnetic Resonance Imaging
  • * Treatment with psychotropic medication as per discretion of the PI
  • * IQ less than 80
  • * Weight exceeding 166kg
  • * Diagnosis of major psychotic or manic disorder in first-degree relatives.
Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks

Location Details

NCT05641766

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How to Participate

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Locations

Not yet recruiting

United States, Connecticut

VA Connecticut Healthcare System, Yale School of Medicine

West Haven, Connecticut, United States, 06516