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NCT05597410 | RECRUITING | Alzheimer Disease

Shanghai At Risk for Alzheimer's Disease: a Cohort Study
Sponsor:

Ruisin Hospital

Brief Summary:

The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.

Condition or disease

Alzheimer Disease

Dementia

Neurodegenerative Diseases

Cognitive Impairment

Neurocognitive Disorders

Detailed Description:

This study is a prospective cohort study focusing on the first-degree relatives of patients with Alzheimer's disease (AD). Multiple methods including the neuropsychiatric assessment battery, magnetic resonance imaging (MRI) and fluid biomarkers (blood and urine) are used to estimate the longitudinal changes of the participants at high risk of AD. Besides, a structured questionnaire is designed to investigate how environmental, behavioral and other factors influence the incidence of AD. This study is of great significance in establishing novel guidelines for the prevention and treatment of dementia suitable for Chinese population, and for clinicians to predict the risk of AD in first-degree relatives.

Study Type : OBSERVATIONAL
Estimated Enrollment : 3418 participants
Official Title : Shanghai At Risk for Alzheimer's Disease: a Cohort Study
Actual Study Start Date : 2022-03-01
Estimated Primary Completion Date : 2029-03
Estimated Study Completion Date : 2030-03

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 50 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • 1. the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
  • 2. not patients with dementia;
  • 3. ≥ 50 years, males and females;
  • 4. subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
  • 5. subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.
  • Exclusion criteria
    • Individuals will be excluded if they have
      • 1. other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;
      • 2. history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);
      • 3. uncorrectable visual or auditory impairment that hampers the completion of related examination.
      • 4. pre-menopausal women will also be excluded.
Shanghai At Risk for Alzheimer's Disease: a Cohort Study

Location Details

NCT05597410

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How to Participate

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Locations

RECRUITING

China, Shanghai Municipality

Ru I enter hospital, Shanghai J i AO tong university school of medicine

Shanghai, Shanghai Municipality, China, 200025