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NCT05595460 | RECRUITING | SCLC,Extensive Stage

Study of RYZ101 in Combination with SoC in Subjects with SSTR+ ES-SCLC
Sponsor:

RayzeBio, Inc.

Brief Summary:

This study aims to determine the safety, preliminary antitumor activity, and pharmacokinetics (PK) of RYZ101 in combination with standard of care (SoC) therapy consisting of carboplatin + etoposide + atezolizumab in untreated subjects with somatostatin receptor expressing (SSTR+) ES-SCLC.

Condition or disease

SCLC,Extensive Stage

Intervention/treatment

RYZ101 Dose Level 1

RYZ101 Dose Level 2

RYZ101 Dose Level 3

RYZ101 Dose Level -1

Atezolizumab

Carboplatin

Etoposide

Phase

PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 31 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Phase 1b Single Arm, Open-label Trial of RYZ101 in Combination with Carboplatin + Etoposide + Atezolizumab in Subjects with Somatostatin Receptor Expressing (SSTR+) Extensive Stage Small Cell Lung Cancer (ES-SCLC)
Actual Study Start Date : 2022-10-10
Estimated Primary Completion Date : 2027-03
Estimated Study Completion Date : 2029-03

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Subjects must meet all the following criteria for enrollment in the study
  • Cytologically or histologically confirmed proven ES-SCLC and is untreated or received ≤1 cycle of platinum-etoposide and PD-L1 inhibitor therapy (including SoC administered during screening, if applicable).
  • Subject is a candidate for therapy with SoC which includes
    • Carboplatin for a maximum of 4 cycles
    • Etoposide for a maximum of 4 cycles
    • Atezolizumab
    • Eastern Cooperative Oncology Group (ECOG) PS 0-1.
    • Life expectancy of at least 12 weeks.
    • SSTR-PET positive
    • Sufficient renal function
    • Adequate hematologic function
    • Adequate hepatic function
    • Woman of childbearing potential (WOCBP) must have a negative serum pregnancy test within 48 hours prior to the first dose of study drug and agree to use barrier contraception and a second form of highly effective contraception or total abstinence while receiving study drug and for 6 months following their last dose of RYZ101/SoC.
    • Sexually active male subjects must use a condom during intercourse while receiving study drug and for 3 months after the last dose of the study drug and should not father a child during this period. If sexual partners are WOCBP must also agree to use a second form of highly effective contraception or total abstinence while receiving study drug and for 3 months following their last dose of RYZ101/SoC.
    • Able to read and/or understand the details of the study and provide written informed consent prior to any study-specific assessments and procedures commence
    • Subjects who meet any of the following criteria will be excluded from the study
      • Prior exposure to immune-mediated therapy excluding anticancer vaccines and excluding 1 cycle of SoC therapy administered during the screening period.
      • Known active or suspected autoimmune disease, including paraneoplastic syndromes of autoimmune nature.
      • Prior PRRT
      • Known hypersensitivity to 225Ac, 68Ga, 64Cu, octreotate, or any of the excipients of DOTATATE imaging agents.
      • Known hypersensitivity to Chinese hamster ovary cell products or to any component of the atezolizumab formulation.
      • History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins.
      • History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan.
      • Severe infection within 4 weeks prior to initiation of study treatment
      • Treatment with therapeutic oral or i.v. antibiotics within 2 weeks prior to initiation of study treatment
      • Prior allogeneic stem cell or solid organ transplantation
      • Treatment with a live, attenuated vaccine within 4 weeks prior to initiation of study treatment, or anticipation of need for such a vaccine during atezolizumab treatment or within 5 months after the final dose of atezolizumab.
      • Any contraindication to receive carboplatin or etoposide. Radiotherapy to the chest prior to systemic therapy or planned consolidation chest radiation therapy or prior external beam radiation therapy to more than 25% of the bone marrow.
      • Major surgery within 4 weeks prior to first dose of study drug.
      • Prior participation in any interventional clinical study within 30 days prior to first dose of study drug.
      • Significant cardiovascular disease, such as New York Heart Association (NYHA) Class ≥II heart failure. QT interval corrected for heart rate using Fridericia's formula (QTcF) \>470 ms.
      • Resistant hypertension, defined as uncontrolled blood pressure (BP) \>140/90 mmHg while on optimal doses of at least 3 antihypertensive medications with 1 being a diuretic (Whelton et al. 2018). Subjects with baseline hypertension may be eligible after initiation of antihypertensive therapy.
      • Have a history of primary malignancy within the past 3 years other than (1) SCLC, (2) adequately treated carcinoma in situ or non-melanoma carcinoma of the skin, (3) any other curatively treated malignancy that is not expected to require treatment for recurrence during participation in the study, or (4) an untreated cancer on active surveillance that may not affect survival status for ≥3 years based on clinician assessment/statement and with Medical Monitor approval.
      • Previously treated central nervous system (CNS) metastases who have not recovered from acute side effects of radiotherapy
      • Active infections such as tuberculosis, hepatitis B or C virus or HIV, or are current treatment with antiviral therapy for HBV.
      • Pregnancy or lactation.
      • Unable or unwilling to comply with the requirements of the study protocol
Study of RYZ101 in Combination with SoC in Subjects with SSTR+ ES-SCLC

Location Details

NCT05595460

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, California

Research Facility

Los Angeles, California, United States, 90024

RECRUITING

United States, California

Research Facility

San Francisco, California, United States, 94158

RECRUITING

United States, Florida

Research Facility

Jacksonville, Florida, United States, 32224

RECRUITING

United States, Florida

Research Facility

Miami, Florida, United States, 33136

RECRUITING

United States, Florida

Research Facility

Orlando, Florida, United States, 32806

RECRUITING

United States, Florida

Research Facility

Tamarac, Florida, United States, 33612

RECRUITING

United States, Iowa

Research Facility

Iowa City, Iowa, United States, 52242

RECRUITING

United States, Kentucky

Reserach Facility

Lexington, Kentucky, United States, 40536

RECRUITING

United States, Road cancer

Research Facility

Grand Rapids, Road cancer, United States, 49503

RECRUITING

United States, Road cancer

Research Facility

Troy, Road cancer, United States, 48098

RECRUITING

United States, Minnesota

Research Facility

Rochester, Minnesota, United States, 55905

RECRUITING

United States, Missouri

Research Facility

Saint Louis, Missouri, United States, 63130

RECRUITING

United States, Nebraska

Research Facility

Omaha, Nebraska, United States, 68130

RECRUITING

United States, Texas

Research Facility

Houston, Texas, United States, 77090

RECRUITING

United States, Utah

Research Facility

Salt Lake City, Utah, United States, 84112

RECRUITING

Puerto Rico,

Research Facility

San Juan, Puerto Rico, 00935