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NCT05558137 | Completed | Onset Time of Mivacurium, Duration of Action of Mivacurium

Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients
Sponsor:

Matias Vested

Information provided by (Responsible Party):

Matias Vested

Brief Summary:

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of mivacurium 0.2 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years.

Condition or disease

Onset Time of Mivacurium, Duration of Action of Mivacurium

Intervention/treatment

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Detailed Description:

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of mivacurium 0.2 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years. The hypothesis of this study is that mivacurium administered in elderly patients (>80 years) has a longer onset time and duration of action compared to younger patients.}}

Study Type : Observational
Estimated Enrollment : 70 participants
Official Title : An Observational Study of Mivacurium 0.2 mg/kg, Comparing Onset Time, Duration of Action and Effect on Intubating Conditions in Young (18 - 40 Years) and Elderly (= 80 Years) Patients
Actual Study Start Date : September 30, 2022
Estimated Primary Completion Date : May 22, 2023
Estimated Study Completion Date : May 25, 2023

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Patients ≥ 80 or ≥ 18 to ≤ 40 years of age
  • Informed consent
  • Scheduled for elective surgery under general anaesthesia (expected duration of anaesthesia > 1 hour) with intubation and use of mivacurium
  • American Society of Anesthesiologists (ASA) physical status classification I to III
  • Can read and understand Danish
Exclusion Criteria
  • Known allergy to mivacurium
  • Neuromuscular disease that may interfere with neuromuscular monitoring
  • Indication for rapid sequence induction
  • Surgery in the prone position
  • Known butyrylcholinesterase deficiency
Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients

Location Details

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Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients

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Locations

Not yet recruiting

Denmark,

Rigshospitalet

Copenhagen, Denmark, 2100