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NCT05557864 | RECRUITING | Parkinson's Disease

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
Sponsor:

University of Minnesota

Brief Summary:

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Condition or disease

Parkinson's Disease

Intervention/treatment

Deep Brain Stimulation

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 24 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2
Actual Study Start Date : 2016-08-25
Estimated Primary Completion Date : 2026-12-31
Estimated Study Completion Date : 2026-12-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 21 Years to 89 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * diagnosis of idiopathic PD
  • * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
  • * Existing 7T brain imagery
Exclusion Criteria
  • * history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
  • * other significant neurological disorder
  • * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
  • * post-operative complications or adverse effects
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Location Details

NCT05557864

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Locations

RECRUITING

United States, Minnesota

University Of Minnesota

Minneapolis, Minnesota, United States, 55455