Thinking of joining a study?

Register your interest

NCT05557760 | Recruiting | Major Depression in Remission


Effects of Booster Sessions on Depression Vulnerability Following Cognitive Control Training
Sponsor:

University Ghent

Brief Summary:

The current study aims to examine the impact of booster sessions of cognitive control training (CCT) on indicators of depression vulnerability. Remitted depressed individuals (RMD) will be randomized over two groups, each receiving 10 sessions of the adaptive Paced Auditory Serial Addition Task, a well-established CCT procedure (Koster et al., 2017; Siegle et al., 2007). During and following completion of the training procedure, functioning will be monitored on a weekly basis over a period of 15 weeks. During this period, one group will be offered booster sessions based on early warning signs for possible recurrence of depression, whilst the other group will not receive booster sessions.

Condition or disease

Major Depression in Remission

Intervention/treatment

Cognitive Control Training (CCT)

Cognitive Control Training (CCT) + Booster Sessions

Phase

Not Applicable

Detailed Description:

Cognitive impairments are closely associated with depression and recent studies have found that these cognitive problems can persist following remission of depression. Internet-delivered cognitive control training (CCT), and the adaptive Paced Auditory Serial Addition Task (aPASAT) in particular, has shown to be an effective preventative intervention for remitted depressed individuals (RMD), where beneficial effects have been found for rumination, depressive symptomatology (Hoorelbeke & Koster, 2017), and risk for recurrence of depression (Hoorelbeke et al., 2021). At the same time, prior studies suggest significant heterogeneity in response to CCT, where RMD individuals can show strong fluctuations in functioning in the months following completion of aPASAT training. In line with this, recent findings suggest that, for individuals with high-risk profiles, initial training gains may diminish over time, resulting in recurrence of internalizing symptomatology (Hoorelbeke et al., 2022). As such, there may be merit in the use of CCT booster sessions. Currently, it is unclear whether offering additional CCT sessions when RMD individuals are reporting increased symptomatology (i.e., adding booster sessions based on early warning signs for possible recurrence of depression) can increase the long-term effectiveness of CCT. In this study, two groups of RMD individuals will perform 10 CCT sessions, after which one group will be offered booster sessions (contingent on indicators of functioning). For this purpose, we will rely on 15 weekly mobile assessments, using the PHQ-9 questionnaire. In addition, functioning will be assessed using a more extensive assessment battery at baseline, post-training (2 weeks after baseline) and follow-up (15 weeks after baseline).}}

Study Type : Interventional
Estimated Enrollment : 138 participants
Masking : None (Open Label)
Primary Purpose : Prevention
Official Title : Evaluating the Effects of Personalized Booster Sessions on Depression Vulnerability Following Cognitive Control Training for Remitted Depressed Individuals
Actual Study Start Date : October 18, 2022
Estimated Primary Completion Date : September 30, 2024
Estimated Study Completion Date : September 30, 2024
Arm Intervention/treatment

Experimental: Cognitive Control Training Group

Behavioral: Cognitive Control Training (CCT)

Experimental: Cognitive Control Training + Booster Sessions Group

Behavioral: Cognitive Control Training (CCT) + Booster Sessions

Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • History of ≥ 1 depressive episode(s)
  • Currently in remission (≥ 3 months)
  • Access to a computer with an internet connection
  • Access to a smartphone
Exclusion Criteria
  • Ongoing depressive episode
  • Psychotic disorder (current and/or previous)
  • Neurological impairments (current and/or previous)
  • Excessive substance abuse (current and/or previous)
  • Use of antidepressant medication is allowed if kept at a constant level

Effects of Booster Sessions on Depression Vulnerability Following Cognitive Control Training

Location Details


Please Choose a site



Effects of Booster Sessions on Depression Vulnerability Following Cognitive Control Training

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Not yet recruiting

Belgium, East Flanders

Ghent University Hospital

Ghent, East Flanders, Belgium, 9000

Recruiting

Belgium, East Flanders

Ghent University

Ghent, East Flanders, Belgium, 9000

Loading...