University of Utah
Benjamin Lewis
This project is an open-label randomized study looking at an 8-week Mindfulness-Based Stress Reduction (MBSR) curriculum vs. an 8-week MBSR curriculum + a group psilocybin-assisted psychotherapy intervention for frontline healthcare providers struggling with symptoms of depression and burnout associated with the SARS-CoV-2 pandemic. Following consenting and enrollment a total of 24 participants will be randomized to receive either an 8-week MBSR curriculum or the same 8-week MBSR curriculum + a group psilocybin-assisted psychotherapy intervention. The group psilocybin-assisted psychotherapy intervention will involve 3 group preparatory sessions (2 hours each), a single 8 hour group psilocybin administration session with a 1:1 therapist to participant ratio (25mg psilocybin dose), and 3 group integration sessions (2 hours each).
Depression
Burnout, Professional
Psilocybin
Mindfulness-Based Stress Reduction (MBSR)
Early Phase 1
Study Type : | Interventional |
Estimated Enrollment : | 24 participants |
Masking : | None (Open Label) |
Primary Purpose : | Treatment |
Official Title : | PAPR: Psilocybin-assisted Psychotherapy + Mindfulness-Based Stress Reduction (MBSR) for Front-line Healthcare Provider COVID-19 Related Burnout |
Actual Study Start Date : | January 2, 2023 |
Estimated Primary Completion Date : | January 1, 2024 |
Estimated Study Completion Date : | January 1, 2024 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Mindfulness-Based Stress Reduction (MBSR) Participants in the MBSR arm will complete an 8-week Mindfulness-Based Stress Reduction Curriculum involving a weekly 2 hour group meeting (either in person or virtual) as well as a 8 hour group mindfulness retreat in week 6-7 of the curriculum. |
Behavioral: Mindfulness-Based Stress Reduction (MBSR) |
Experimental: Mindfulness-Based Stress Reduction (MBSR) + Psilocybin-Assisted Psychotherapy (PAP) Participants in the MBSR + PAP arm will complete an 8-week Mindfulness-Based Stress Reduction Curriculum involving a weekly 2 hour group meeting (either in person or virtual). They will additionally complete a psilocybin-assisted psychotherapy (PAP) intervention that involves three 2-hour group preparatory sessions, a single 8-hour group psilocybin administration session (done in place of the mindfulness retreat), and three 2-hour group integration sessions. All PAP intervention sessions will utilize a 1:1 therapist to participant ratio with an additional lead therapist present. |
Drug: Psilocybin |
Ages Eligible for Study: | 25 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Huntsman Mental Health Institute
Salt Lake City, Utah, United States, 84108