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NCT05553873 | RECRUITING | Myeloproliferative Disease

Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.
Sponsor:

University of Milan Bicocca

Brief Summary:

This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification

Condition or disease

Myeloproliferative Disease

Inflammatory Markers

Study Type : OBSERVATIONAL
Estimated Enrollment : 500 participants
Official Title : Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.
Actual Study Start Date : 2022-09-08
Estimated Primary Completion Date : 2026-12
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 99 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age ≥ 18 years at the time of diagnosis of MPN Ph negative
  • * Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)
  • * Obtaining informed consent
Exclusion Criteria
  • * Life expectancy of less than 6 months
  • * Accelerated phase myelofibrosis or MPN with signs of leukemic evolution
Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

Location Details

NCT05553873

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

Italy,

Polyclinic Consortium Hospital University Hospital

Bari, Italy,

RECRUITING

Italy,

Polyclinic Sant'Orsola Malpighi

Bologna, Italy,

RECRUITING

Italy,

ASST Civil Spedali di Brescia

Brescia, Italy,

RECRUITING

Italy,

Vittorio Emanuele Polyclinic

Catania, Italy,

RECRUITING

Italy,

Federico II University Hospital

Napoli, Italy,

RECRUITING

Italy,

Policlinico Umberto I, La Sapienza University

Roma, Italy,

RECRUITING

Italy,

University Hospital City of Health and Science City

Torino, Italy,

RECRUITING

Italy,

San Luigi di Orbassano Hospital - Mauritian hospital

Torino, Italy,

RECRUITING

Italy,

Friuli Centrale University Hospital

Udine, Italy,

RECRUITING

Italy,

Integrated University Hospital

Verona, Italy,

RECRUITING

Italy,

Belcolle Hospital

Viterbo, Italy,