The Hospital for Sick Children
Giles Santyr
To evaluate the feasibility of hyperpolarized 129Xe MRI in lung transplant recipients and assess structural and functional pulmonary changes using hyperpolarized 129Xe MRI
Lung Transplant Rejection
129Xenon
Phase 2
Lung transplantation is an effective treatment for end-stage lung disease. However, median survival post-LTx is 6 years. This is primarily due to chronic lung allograft dysfunction (CLAD). Clinical management of LTx recipients is focused on identifying early risk factors for CLAD, by monitoring graft function with spirometry and transbronchial biopsies. However, both have significant limitations. Hyperpolarized (HP) noble gas lung MRI (3He and 129Xe) allows mapping of both lung anatomy and function. 129Xe-MRI could provide a diagnostic tool that is able to detect CLAD more sensitively and earlier than the current gold standard measurements of spirometry and plethysmography, and thus allow a means to detect and prevent /slow down irreparable and irreversible damage to the lungs in the early stages of disease.}}
Study Type : | Interventional |
Estimated Enrollment : | 15 participants |
Masking : | None (Open Label) |
Primary Purpose : | Screening |
Official Title : | Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Chronic Lung Allograft Dysfunction in Lung Transplant Recipients |
Actual Study Start Date : | February 7, 2024 |
Estimated Primary Completion Date : | October 15, 2024 |
Estimated Study Completion Date : | December 31, 2024 |
Arm | Intervention/treatment |
---|---|
Experimental: Single arm Participants will inhale hyperpolarized 129Xe gas. |
Drug: 129Xenon |
Ages Eligible for Study: | 18 Years to 75 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Recruiting
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8