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NCT05496582 | Not yet recruiting | Asthma


The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma
Sponsor:

Shanghai University of Traditional Chinese Medicine

Brief Summary:

Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.

Condition or disease

Asthma

Intervention/treatment

No intervention

Detailed Description:

This study will investigate the changes and associations in asthma. In this project, the investigators will explore the changes of gene expression of transgelin-2, metallothionein-2 and ezrin in asthma and investigate their correlation with current diagnosis markers of asthma, including pulmonary function, fractional exhaled nitric oxide,eosinophil counts,immunoglobulin E, interleukin-5, etc.}}

Study Type : Observational
Estimated Enrollment : 100 participants
Official Title : The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma: A Case-control Study
Actual Study Start Date : August 2022
Estimated Primary Completion Date : August 2024
Estimated Study Completion Date : August 2025

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 14 Years to 75 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • Males or females, aged 14-75 years;
  • Patients with a definite diagnosis of bronchial asthma;
  • The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
  • Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
  • Agree with all procedures in this trial by signing a written informed consent form.
Exclusion Criteria
  • Patients with chronic obstructive pulmonary disease or other airway disease;
  • Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
  • Women who are known to be pregnant or breastfeeding;
  • Not willing to participate;
  • Psychiatric history and neurological disorders can not work normally;
  • Other conditions that the researcher considers inappropriate to participate in this study.

The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

Location Details


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The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Not yet recruiting

China, Hunan

Xiangya Hospital, Central South University

Changsha, Hunan, China, 410000

Not yet recruiting

China, Shanghai

Yueyang Hospital, Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai, China, 200030

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