Thinking of joining a study?

Register your interest

Become a volunteer?

NCT05419076 | RECRUITING | Lung Cancer

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Sponsor:

Memorial Sloan Kettering Cancer Center

Brief Summary:

The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.

Condition or disease

Lung Cancer

Lung Cancer Metastatic

Brain Metastases

Brain Metastases, Adult

Small-cell Lung Cancer

Small Cell Lung Carcinoma

Intervention/treatment

Stereotactic Radiosurgery

Cerebrospinal fluid collection

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 62 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Single Arm Phase II Study Assessing Efficacy of Stereotactic Radiosurgery (SRS) for Brain Metastasis (BM) From Small Cell Lung Cancer (SCLC)
Actual Study Start Date : 2022-06-10
Estimated Primary Completion Date : 2025-06-10
Estimated Study Completion Date : 2025-06-10

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Histologic diagnosis of small cell lung cancer
  • * Radiographic diagnosis of up to 10 brain metastases on contrast-enhanced MRI
  • * Age 18 and above
  • * Performance status KPS 60-100/ECOG 0-2
  • * Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
  • * The patient or legally authorized representative is able to provide informed consent
Exclusion Criteria
  • * Unable to undergo contrast-enhanced MRI brain or spine
  • * Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
  • * Pregnant or lactating women
  • * Prior brain-directed radiotherapy
  • * Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Location Details

NCT05419076

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Connecticut

Hartford Healthcare (Data Collection Only)

Hartford, Connecticut, United States, 06102

RECRUITING

United States, New Jersey

Memorial Sloan Kettering at Basking Ridge

Basking Ridge, New Jersey, United States, 07920

RECRUITING

United States, New Jersey

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, United States, 07748

RECRUITING

United States, New Jersey

Memorial Sloan Kettering Bergen

Montvale, New Jersey, United States, 07645

RECRUITING

United States, New York

Memorial Sloan Kettering Suffolk - Commack

Commack, New York, United States, 11725

RECRUITING

United States, New York

Memorial Sloan Kettering Westchester

Harrison, New York, United States, 10604

RECRUITING

United States, New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, United States, 10065

RECRUITING

United States, New York

Memorial Sloan Kettering Nassau

Rockville Center, New York, United States, 11553