Philipps University Marburg Medical Center
The study tries to identify whether specifically framed expectations, induced with an active placebo nasal-spray, have effects on affective regulation processes and rumination.
Social Anxiety
Depression
Active Placebo labelled as antidepressant
Not Applicable
Healthy volunteers are informed that a new application method for an antidepressant, specialized on positively influencing the experience of aversive emotional states would be tested. They will randomly be assigned to a no treatment control group (not taking a placebo) or to one of the two treatment groups: Participants will be taking the antidepressant (which is in fact an active placebo) which will either protect them from experiencing intense emotional reactions and rumination (anticipatory group) or help them to regulate emotional states quicker as well as to distance themselves from ruminative thoughts (reactive group). Then, an aversive emotional state is induced by an autobiographical recall of events which made the participants feel inadequate, bashful, and ashamed. Currently experienced shame as well as state rumination are assessed before and after the negative recall task.}}
| Study Type : | Interventional |
| Estimated Enrollment : | 127 participants |
| Masking : | None (Open Label) |
| Primary Purpose : | Treatment |
| Official Title : | The Influence of Expectations on Affect-regulatory Characteristics of Deceptive Placebos: An Experimental Investigation |
| Actual Study Start Date : | May 25, 2022 |
| Estimated Primary Completion Date : | July 31, 2022 |
| Estimated Study Completion Date : | July 31, 2022 |
| Arm | Intervention/treatment |
|---|---|
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Experimental: Experimental group (anticipatory) Participants receive a nasal spray that is in fact a placebo. However, they are told that it protects from experiencing intensive emotional reactions and consequent rumination tendencies. They take the nasal spray once in the laboratory. |
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Experimental: Experimental group (reactive) Participants receive a nasal spray that is in fact a placebo. Participants of this group are told, however, that it helps to regulate experienced intensive emotional reactions and to distance oneself from consequent ruminative thoughts. They take the nasal spray once in the laboratory. |
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No Intervention: No-treatment control group Participants do not receive the nasal spray and continue with the following task. |
| Ages Eligible for Study: | 18 Years to 75 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Philipps University of Marburg
Marburg, Germany, 35037