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NCT05370664 | Not yet recruiting | COPD Exacerbation

Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Women; Cohort Study
Sponsor:

Assiut University

Information provided by (Responsible Party):

Khaled Essmat Hussien

Brief Summary:

Assess predictors of mortality in COPD exacerbation between men and women. Evaluate the clinical outcomes in acute exacerbation of COPD in women. Evaluate the validity of new scoring systems ( NIVO, DECAF, HACOR ) as a predictor for hospital outcome in acute exacerbation of COPD. Compare these new scoring system with the most widely used APACHE IV. Assessment of serum level of granulocyte colony stimulating factor ( GM-CSF) in detecting the severity of COPD exacerbation.

Condition or disease

COPD Exacerbation

Study Type : Observational
Estimated Enrollment : 203 participants
Official Title : Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Women; Cohort Study
Actual Study Start Date : July 2022
Estimated Primary Completion Date : July 2024
Estimated Study Completion Date : April 2025

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 35 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Patients with AECOPD leading to hypoxemia, hypercapnia and respiratory acidosis with pH < 7.35 and PaCO2 > 45 mm of Hg will be admitted to the respiratory intensive care unit (ICU) for NIV or the ward will be eligible for inclusion and not in need for mechanical ventilation
Exclusion Criteria
  • Requirement for emergency intubation.
  • Other contraindications to NIPPV including cardiac or respiratory arrest; nonrespiratory organ failure (eg, severe encephalopathy, severe gastrointestinal bleeding, hemodynamic instability with or without unstable cardiac angina); facial surgery or trauma; upper-airway obstruction; inability to protect the airway and/or high risk of aspiration; and inability to clear secretions.(6)
  • Age < 35 years.
Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Women; Cohort Study

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Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Women; Cohort Study

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