Yonsei University
Although there have been studies regarding intensive lowering of low-density lipoprotein (LDL)-cholesterol with high intensity statins in patients with cardiovascular disease, elderly patients were either excluded or accounted only a small portion of study subjects. Therefore, this study sought to compare the clinical outcomes according to the LDL-cholesterol therapy targeting (intensive targeting [LDL-cholesterol <55mg/dL] vs. conventional therapy [moderate intensity statin therapy]) in elderly patients with ≥75 years and documented cardiovascular disease.
Cardiovascular Disease
Intensive targeting group
Conventional therapy group
Phase 4
| Study Type : | Interventional |
| Estimated Enrollment : | 1200 participants |
| Masking : | None (Open Label) |
| Primary Purpose : | Treatment |
| Official Title : | Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial |
| Actual Study Start Date : | July 19, 2022 |
| Estimated Primary Completion Date : | October 15, 2025 |
| Estimated Study Completion Date : | October 15, 2027 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Intensive targeting group Intensive lipid loweroing therapy with LDL-cholesterol goal of <55mg/dL |
Drug: Intensive targeting group |
|
Active Comparator: Conventional therapy group Initiate and maintain moderate intensity statin therapy |
Drug: Conventional therapy group |
| Ages Eligible for Study: | 75 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
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Recruiting
Yonsei University Health System, Severance Hospital
Seoul, Korea, Republic of,