University Hospital Freiburg
Nils Nicolay
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
HNSCC
Oral Cavity Cancer
Oropharynx Cancer
Hypopharynx Cancer
Larynx Cancer
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 1500 participants |
| Official Title : | Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy |
| Actual Study Start Date : | 2021-06-01 |
| Estimated Primary Completion Date : | 2026-12-31 |
| Estimated Study Completion Date : | 2026-12-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 65 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
COMPLETED
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21287
COMPLETED
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10017
COMPLETED
Department of Radiation Oncology, Case Western Reserve University
Cleveland, Ohio, United States, 10900
COMPLETED
Division of Radiation Oncology, The Ohio State University Wexner
Columbus, Ohio, United States, 43201
COMPLETED
Radiation Oncology Department, German Oncology Center
Limassol, Cyprus,
COMPLETED
Brno University Hospital
Brno, Czechia,
COMPLETED
Department of Radiooncology and Radiotherapy, Charité University Medicine Berlin
Berlin, Germany,
COMPLETED
Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg
Erlangen, Germany,
COMPLETED
Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main
Frankfurt, Germany,
COMPLETED
University of Giessen
Pour, Germany,
COMPLETED
Martin Luther University Halle-Wittenberg
Halle, Germany,
RECRUITING
Jena University Hospital
Jena, Germany,
COMPLETED
Department of Radiation Oncology, University Hospital Schleswig-Holstein
As, Germany,
COMPLETED
Department of Radiation Oncology, University Medical Center Leipzig
Leipzig, Germany,
COMPLETED
Department of Radiation Oncology, University Medical Center Mainz
Mainz, Germany,
COMPLETED
Department of Radiation Oncology, University Hospital, LMU Munich
Munich, Germany,
COMPLETED
Department of Radiation Oncology, University Hospital Würzburg
Würzburg, Germany,
COMPLETED
Department of Radiation Oncology, University Hospital Zurich (USZ), University of Zurich (UZH)
Zürich, Switzerland,