Thinking of joining a study?

Register your interest

Become a volunteer?

NCT05332457 | RECRUITING | Atrial Fibrillation

The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation
Sponsor:

National Taiwan University Hospital

Brief Summary:

This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).

Condition or disease

Atrial Fibrillation

Intervention/treatment

Reduced dosage of beta-blocker

Phase

NA

Detailed Description:

Rate control therapy is the first-line treatment for atrial fibrillation (AF). Resting heart rate(HR) is the treatment target of rate control therapy in current clinical practice; However, the optimal value for resting heart rate in AF remained unclear. Beta-blocker(BB) is widely used as rate-control agent. It is concerned that excessive use of BB might lead to a negative effect on exercise capacity in patients with AF. The aim of this study is to explore the effect of Beta-blocker on hemodynamic parameters and peak oxygen uptake during cardiopulmonary exercise test (CPET).

Study Type : INTERVENTIONAL
Estimated Enrollment : 40 participants
Masking : SINGLE
Masking Description : The outcome assessor are blinked to participants' allocation group.
Primary Purpose : TREATMENT
Official Title : The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation: a Crossover Randomized Controlled Trial.
Actual Study Start Date : 2025-07-01
Estimated Primary Completion Date : 2025-07-31
Estimated Study Completion Date : 2025-12-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 20 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. \> 20 years of age.
  • 2. Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months.
  • 3. Resting heart rate \< 80 bpm.
  • 4. Left ventricular ejection fraction \> 50%.
Exclusion Criteria
  • 1. Beta-blocker usage due to indications other than rate control for atrial fibrillation.
  • 2. Inability to perform a cardiopulmonary exercise testing.
  • 3. Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription.
  • 4. Patients with implantable cardioverter defibrillator or pacemaker.
  • 5. Pregnancy.
  • 6. Inability to provide informed consent.
The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation

Location Details

NCT05332457

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

Taiwan,

National Taiwan University Hospital

Taipei, Taiwan, 100