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NCT05201014 | RECRUITING | Cardiovascular Diseases

Cancer Survivor Cardiomyopathy Detection
Sponsor:

Mayo Clinic

Information provided by (Responsible Party):

Joerg Herrmann, MD

Brief Summary:

The purpose of this study is to improve the cardiovascular care of adult cancer survivors. The goal is to obtain the data necessary to plan and develop a nation-wide network of a screening program that can help provide cost-effective and long-term monitoring.

Condition or disease

Cardiovascular Diseases

Cancer

Intervention/treatment

NT-pro-BNP

Electrocardiogram

Echocardiogram

Detailed Description:

The primary objective of this study is to define the diagnostic performance and optimal cutoffs of AI-ECG and NT-pro-BNP for the detection of left ventricular dysfunction \[LVD, defined as a left ventricular ejection fraction (LVEF) \<50%\] in cancer patients at 1 year after completion of anthracycline-based chemotherapy.

Study Type : OBSERVATIONAL
Estimated Enrollment : 200 participants
Official Title : CAncer Survivor CArdiomyopathy DEtection Pilot Study
Actual Study Start Date : 2022-03-03
Estimated Primary Completion Date : 2026-09-20
Estimated Study Completion Date : 2026-09-20

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 99 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * ≥18 years of age prior to enrollment and anthracycline start date
  • * Diagnosis of breast cancer, lymphoma, or sarcoma with either planned or at 1 year after completion of anthracycline therapy, including patients from 6-12 months and greater than 1 year post-anthracycline exposure.
  • * Patients with a history of persistent atrial fibrillation (afib) that are not in afib remission. Include if the most recent ECG does not show afib. Atrial flutter treated the same
Exclusion Criteria
  • * LVEF \<50% or prior confirmed history of cardiomyopathy, heart failure, left bundle branch block, or paced rhythm
  • * Patients with a history of persistent atrial fibrillation (afib) that are not in afib remission. Include if the most recent ECG does not show afib. Atrial flutter treated the same.
  • * Individuals with pacemakers, defibrillators, or other implanted electronic devices
  • * Inability/unwillingness of individual to give written informed consent
Cancer Survivor Cardiomyopathy Detection

Location Details

NCT05201014

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Minnesota

Mayo Clinic in Rochester

Rochester, Minnesota, United States, 55905