The Affiliated Hospital of Xuzhou Medical University
CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.
Acute Ischemic Stroke
Quantitative Real-time polymerase chain reaction
Circular RNAs have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose of this protocol will investigate the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke. Distinctive expression patterns of circRNA will be identified by individual quantitative real time polymerase chain reaction (qRT-PCR). A diagnostic or predictive model will be established using logistic regression. The panel of these altered circRNAs may be associated with acute IS and could serve as a novel diagnostic or predictive method.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 500 participants |
| Official Title : | Clinical Significance of Circulating circRNA in Acute Ischemic Stroke (CRAST) |
| Actual Study Start Date : | 2020-10-01 |
| Estimated Primary Completion Date : | 2024-10-30 |
| Estimated Study Completion Date : | 2024-10-30 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
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RECRUITING
Department of Neurology
Xuzhou, Jiangsu, China,