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NCT05040659 | RECRUITING | Anosmia

Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
Sponsor:

Massachusetts General Hospital

Information provided by (Responsible Party):

Mark W Albers

Brief Summary:

The purpose of this study is to learn more about how to better track smell recovery in people who have been infected with the SARS-CoV-2 virus (which causes COVID-19). Many people who have been infected by this virus develop changes in their sense of smell (olfaction). We are interested in measuring smell function objectively via smell cards that test odor intensity, identification, and discrimination. Objective and precise olfactory testing that can be performed in the convenience of one's home will help identify people with smell loss after infection by SARS-CoV-2. We will use results from this test to better understand the relationship between SARS-CoV-2 infection and recovery of olfactory function and to learn whether the AROMHA longitudinal smell test is a reliable olfactory function tracking tool to quantify smell loss in the context of COVID infection. These results may inform the design of therapeutic clinical trials to accelerate the recovery of smell function.

Condition or disease

Accomia

Asymptomatic COVID-19

COVID-19 Respiratory Infection

Influenza

Healthy

Intervention/treatment

AROMHA Longitudinal Smell Test

Study Type : OBSERVATIONAL
Estimated Enrollment : 1000 participants
Official Title : Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2
Actual Study Start Date : 2022-11-14
Estimated Primary Completion Date : 2024-12-30
Estimated Study Completion Date : 2025-05-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 100 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
For anosmic patients/healthy controls
  • Inclusion criteria
  • 1. Known anosmia (for anosmic patients only)
  • 2. Age greater than or equal to 18
  • 3. Access to phone, tablet or computer connected to the internet.
  • Exclusion criteria
  • 1. Known odor-evoked adverse effects, e.g. asthma.
  • For asymptomatic participants
    • Inclusion criteria
    • 1. No symptoms of COVID infection at the time of enrollment.
    • 2. Age greater than or equal to 18
    • 3. Access to phone, tablet or computer connected to the internet.
    • Exclusion criteria
    • 1. Known odor-evoked adverse effects, e.g. asthma.
    • For participants with COVID-19-related smell loss
      • Inclusion criteria
      • 1. Past infection of SARS-CoV-2 virus as validated by a previous PCR or antigen test
      • 2. Age greater than or equal to 18
      • 3. Access to phone, tablet or computer connected to the internet.
      • Exclusion criteria
      • 1. Known odor-evoked adverse effects, e.g. asthma.
Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2

Location Details

NCT05040659

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Massachusetts

Massachusetts General Hospital

Boston, Massachusetts, United States, 02129