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NCT05037825 | RECRUITING | Non-Small-Cell Lung Carcinoma

The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
Sponsor:

Fixed biome

Brief Summary:

The microbiome has the potential to serve as a robust biomarker of clinical response to immunotherapy. Additionally, microbial manipulation, through diet, exercise, prebiotics, probiotics, or microbially-derived metabolites, may prove to be beneficial in promoting anti-tumor immune responses. However, large prospective studies in humans with longitudinal sample collection and standardized methods are needed to understand how microbiota and their byproducts affect cancer therapies, particularly among patients undergoing identical therapy but experiencing different outcomes. The proposed observational study builds upon these hypotheses by proposing a large cohort design to further assess the associations between the gut microbiota (composition and function), host immune system, and ICI treatment efficacy across multiple cancer types.

Condition or disease

Non-Small-Cell Lung Carcinoma

Malignant Melanoma

Renal Cell Carcinoma

Triple-Negative Breast Cancer

Intervention/treatment

Checkpoint Inhibitor, Immune

Study Type : OBSERVATIONAL
Estimated Enrollment : 800 participants
Official Title : The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
Actual Study Start Date : 2021-11-22
Estimated Primary Completion Date : 2023-09-14
Estimated Study Completion Date : 2028-09-14

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Men or women ≥18 years of age
  • 2. Screened negative for COVID-19 symptoms at time of consent, as per institutional policy and as applicable for the duration of the COVID-19 pandemic
  • 3. Diagnosed with stages I-IV primary NSCLC, MM, TNBC or RCC
  • 4. Plan to be treated at a partner cancer site with a checkpoint inhibitor (anti-PD-1, anti-PD-L1, or anti-CTLA-4) as a single agent or in combination with another checkpoint inhibitor or other treatment agent or modality (e.g., targeted therapy, chemotherapy, surgery, radiation, etc.) in accordance with FDA-labeled use of the agent
  • 5. Able to provide informed consent and answer study questionnaires in either English or Spanish
  • 6. Able to provide stool specimens for research purposes
Exclusion Criteria
  • 1. Mental incapacity
  • 2. Incarcerated individuals
  • 3. Pregnancy (by self-report of pregnancy status)
  • 4. Experiencing active brain metastasis/metastases
  • 5. Treatment with checkpoint inhibitor in off-label capacity or through a clinical/interventional trial
  • 6. Active participation in an immuno-oncology clinical/interventional trial or pharma-sponsored observational study
The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors

Location Details

NCT05037825

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Kentucky

Baptist Health Clinical Research

Elizabethtown, Kentucky, United States, 42701