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NCT05025774 | NOT YET RECRUITING | Chronic Lung Disease

Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise
Sponsor:

Masonic Cancer Center, University of Minnesota

Brief Summary:

This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))

Condition or disease

Chronic Lung Disease

Chronic Obstructive Pulmonary Disease

Acute Lymphoblastic Leukemia

Heart Transplant

Intervention/treatment

Physical activity

Detailed Description:

Physical activity in childhood is an integral part of maintaining health and quality of life. Children who participate in routine physical activity are more likely to maintain a healthy body weight and are less likely to have heart disease, type 2 diabetes and high blood pressure as adults. Children with chronic disease are often limited from full participation in exercise for various reasons -perceived physical limitations, either from the patient and family or from their medical provider, or because of symptoms which cause exercise to feel uncomfortable. As the number of children living and aging with chronic disease continues to grow, the researchers are hoping to expand the current exercise testing capabilities for both clinical care and research in order to (i) provide data to permit formulation of evidence-based guidelines for exercise in chronic childhood disease; (ii) improve understanding of limitations to exercise in this growing population; (iii) learn long-term implications of chronic childhood disease as these individuals enter adulthood.

Study Type : OBSERVATIONAL
Estimated Enrollment : 90 participants
Official Title : Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant Bronchopulmonary Dysplasia (BPD, Also Known as Chronic Lung Disease of Prematurity) Through Exercise (FLASHLITE)
Actual Study Start Date : 2025-01-01
Estimated Primary Completion Date : 2025-08-01
Estimated Study Completion Date : 2025-08-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 8 Years to 25 Years
Sexes Eligible for Study: ALL
Criteria
Inclusion Criteria
  • * Cases
    • * Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
    • * 8-25 years old
    • * Height: ≥ 48 inches
    • * Ambulatory without assistance
    • * English speaking
    • * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
    • * SpO2 \>92%
    • * Not pregnant
    • * ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
    • * Controls
    • * 8-25 years old
    • * Height: ≥ 48 inches
    • * Ambulatory without assistance
    • * English speaking
    • * No history of arrhythmia or known cardiac dysfunction at baseline
    • * Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
    • * SpO2 \>95%
    • * Not pregnant
    Exclusion Criteria
    • * Cases
      • * ALL specific: received cranial radiation, bone marrow transplant recipients
      • * Investigator or patient's primary physician deems the patient unsuitable for the study
      • * Controls
        • * History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
        • * Investigator deems the patient unsuitable for the study
Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise

Location Details

NCT05025774

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