National University of Singapore
Christopher Chen Li-Hsian
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. The SINGER study is a 2-year randomized controlled trial that aims to test the efficacy and safety of these lifestyle changes, including diet and cardiovascular risk factor management, cognitive and physical exercises, in delaying cognitive decline in older adults at risk of dementia.
Cognitive Impairment
Alzheimer Disease
Vascular Cognitive Impairment
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Cognition Disorder
Structured Lifestyle Intervention
Self-Guided Intervention
NA
Results from a population-based 2-year clinical trial, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), demonstrated that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. Currently, no pharmacological treatment options that can rival these effects. Thus, there is an urgent need to test the generalizability, adaptability, and sustainability of these findings in Singaporean populations. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility and practicality of the FINGER interventions and a set of locally adapted interventions in an Asian population. Hence, the next step was to conduct a larger scale SINGER trial to determine the efficacy of these interventions in Singapore. If the interventions are found to be effective and safe with high applicability and scalability, the study will provide important clinical and public health implications to a rapidly increasing ageing population.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1200 participants |
| Masking : | SINGLE |
| Primary Purpose : | SUPPORTIVE_CARE |
| Official Title : | The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study, Biomarker and Health Service Research Analyses |
| Actual Study Start Date : | 2021-08-23 |
| Estimated Primary Completion Date : | 2025-12-31 |
| Estimated Study Completion Date : | 2026-01-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 60 Years to 77 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
National University Hospital
Singapore, Singapore, 117600
RECRUITING
National University of Singapore, Yong Loo Lin School of Medicine
Singapore, Singapore, 117600
NOT YET RECRUITING
National Neuroscience Institute @ Tan Tock Seng Campus (NNI @ TTSH campus)
Singapore, Singapore, 308433