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NCT04915105 | Not yet recruiting | Dermatologic Disease


Personal Precise Treatment on Psoriasis and Psoriatic Arthritis
Sponsor:

Taichung Veterans General Hospital

Brief Summary:

Part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. Therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians

Condition or disease

Dermatologic Disease

Intervention/treatment

Markers data from PBMCs

Phase

Not Applicable

Detailed Description:

PBMCs isolated from psoriasis and psoriatic arthritis and incubated with Group A streptococcus and different biologics for 24 hours. Cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.

Study Type : Interventional
Estimated Enrollment : 90 participants
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Personal Precise Treatment on Psoriasis and Psoriatic Arthritis and Investigate the Mechanisms of Biological Agents Induced Systemic Lupus Erythematosus
Actual Study Start Date : May 31, 2021
Estimated Primary Completion Date : May 31, 2025
Estimated Study Completion Date : May 31, 2025
Arm Intervention/treatment

Experimental: Prescreen on psoriasis and psoriatic arthritis treatment

Prescreen markers from individual PBMCs and choose proper biologics before starting treatment on psoriasis and psoriatic arthritis patients.

Diagnostic Test: Markers data from PBMCs

Ages Eligible for Study: 20 Years to 70 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • 1. Healthy control without underline disease such as psoriasis and psoriatic arthritis. 2. Psoriasis been diagnosed for over six months and PASI >10. 3.Psoriatic arthritis been diagnosed for over six months and >1 swallow and tender joints
Exclusion Criteria
  • nil

Personal Precise Treatment on Psoriasis and Psoriatic Arthritis

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Personal Precise Treatment on Psoriasis and Psoriatic Arthritis

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