Aarhus University Hospital
Louise Bach Callesen
A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.
Cancer of Gastrointestinal Tract
In this study, the investigators seek to investigate biological aspects in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal. The targeted treatment will be given as per standard of care. Translational blood samples will be drawn pre-treatment, before the third cycle of chemotherapy, and hereafter corresponding to the planned imaging during treatment and follow up. The total cell free DNA will be quantified in all samples. The samples will be analyzed for tumor specific mutations such as the KRAS, BRAF, and NRAS oncogenes, by ddPCR. Circulating tumor DNA will also be identified by hypermethylation markers, and a focused panel of next generation sequencing can be applied. The samples will also be analyzed for immune-related biomarkers. The investigators expect to include up to 130 patients. This is a purely observational translational study. Results will be analysed in relation to outcome data.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 130 participants |
| Official Title : | Rare Subtypes of Gastrointestinal Cancers - Real-world Data and Liquid Biopsies |
| Actual Study Start Date : | 2021-08-16 |
| Estimated Primary Completion Date : | 2025-04-01 |
| Estimated Study Completion Date : | 2026-04-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Department of Oncology, Aarhus University Hospital
Aarhus N, Denmark, 8200