Brain Inflammation Collaborative
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years and older will provide self-reported health data, biometrics, and symptom diaries through the MyDataHelps™ app (branded as unhide® for this study). The goal is to create comprehensive longitudinal profiles to facilitate research into disease subtypes, causes, diagnostics, and potential treatments, as well as to identify potential participants for future optional studies. "Healthy" individuals without brain inflammation are also eligible to participate. The digital health research platform used in this study was originally developed and designed by Solve M.E and was called SolveTogether. The Brain Inflammation Collaborative (BIC) expanded upon Solve M.E.'s work to include related diagnoses, pediatric participants, enhance symptom tracking, and more. BIC and Solve M.E. combined Solve Together and unhide®, to create The unhide® Solve Together Unified Platform in 2025.
Post-Acute COVID-19 Syndrome
ME/CFS
Rheumatic Arthritis
Juvenile Rheumatoid Arthritis (JRA)
Psoriatic Arthritis (PsA)
Ankylosing Spondylitis (AS)
Autoimmune Encephalitis
Bipolar Disorder (BPD)
Celiac Disease
Celiac Disease in Children
Chronic Lyme Disease
Post-treatment Lyme Disease Syndrome
Crohn's Disease
Dysautonomia
Anorexia Nervosa
Bulimia Nervosa
ARFID
Avoidant / Restrictive Food Intake Disorder
Ehlers Danlos Syndrome
Endometriosis
Fibromyalgia (FM)
Long COVID
Lupus
Major Depression
Migraines
Mast Cell Activation Syndrome
Multiple Sclerosis
Myalgic Encephalomyelitis (ME)
Myasthenia Gravis, Generalized
Myasthenia Gravis in Children
Narcolepsy
Obsessive Compulsive Disorder (OCD)
PANDAS
Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
POTS - Postural Orthostatic Tachycardia Syndrome
General Anxiety Disorder, Social Anxiety Disorder
PTSD - Post Traumatic Stress Disorder
Psoriasis
Traumatic Brain Injury
Tourette's Syndrome
Inflammatory Bowel Disease (IBD)
Autoimmune Diseases
Neurological Diseases or Conditions
Psychiatric Disorder
Sjogren's Syndrome
Ulcerative Colitis and Crohn's Disease
The unhide® Project is sponsored by the Brain Inflammation Collaborative (BIC), a nonprofit organization dedicated to advancing understanding, diagnosis, and treatment of neuroinflammatory illness. This study will create a secure, long-term repository of demographic, health, lifestyle, biometric, and symptom data from individuals in the United States with brain inflammation and related conditions, as well as unaffected individuals. Data will be collected remotely through MyDataHelps™ by Care Evolution (rebranded as unhide®), a secure mobile and web-based platform enabling eConsent, survey completion, health record linkage, and optional symptom/activity tracking. Eligible participants are U.S. residents aged 2 years and older, including both self-identified and physician-diagnosed individuals with infection-associated, autoimmune, neuroimmune, inflammatory gastrointestinal, and behavioral/mood disorders, as well as "healthy" individuals. There are minimal exclusion criteria: individuals living outside the U.S., wards of the state, and those with decisional impairment are ineligible. Pregnant women may participate, and prior or concurrent participation in other research studies is permitted. The study will follow participants for 10 or more years, collecting self-reported health information, comorbidities, medical history, biometrics (e.g., heart rate, sleep, activity), and symptom data to generate comprehensive longitudinal health profiles. This data resource aims to accelerate translational research, identify disease subtypes, uncover causes and risk factors, support the development of diagnostic tests and treatments, and improve outcomes for individuals affected by neuroinflammation.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 10000 participants |
| Official Title : | Unhide® Project Also Known as The Unhide® Solve Together Unified Platform |
| Actual Study Start Date : | 2023-07-05 |
| Estimated Primary Completion Date : | 2030-06-30 |
| Estimated Study Completion Date : | 2030-12-31 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 2 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Brain Inflammation Collaborative
Delafield, Wisconsin, United States, 53018