Helsinki University Central Hospital
Ville Sallinen
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when thrombosis prophylaxis should be commenced in patients undergoing liver surgery. As far as we know, there are no prospective randomized trials in this field, and current guidelines are unfortunately based on very low quality evidence, that is, a few retrospective studies and expert opinion. Both American and European thromboprophylaxis guidelines for abdominal cancer surgery support the preoperative initiation of thromboprophylaxis, but these guidelines do not specifically address the increased bleeding risk associated with liver surgery. On the contrary, Dutch guidelines recommend postoperative thromboprophylaxis only, because of lack of evidence for preoperative thromboprophylaxis. Traditionally, many liver surgery units have been reluctant in using preoperative thromboprophylaxis due to the potentially increased risk of bleeding complications. Enhanced Recovery After Surgery (ERAS) Society Guidelines recommend preoperative thromboprophylaxis in liver surgery, but the guidelines provide no supporting evidence for this recommendation. Overall, the amount of evidence is scarce and somewhat contradictory in this clinically relevant field of thromboprophylaxis in liver surgery. The aim of this study is to compare pre- and postoperatively initiated thromboprophylaxis regimens in liver surgery in a randomized controlled trial.
Liver Cancer
Surgery
Thrombosis, Deep Vein
Embolism, Pulmonary
Bleeding
enoxaparin or tinzaparin or dalteparin
No intervention
PHASE4
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1012 participants |
| Masking : | TRIPLE |
| Primary Purpose : | PREVENTION |
| Official Title : | Pre- Vs Postoperative Thromboprophylaxis for Liver Resection - a Prospective, Multicenter, Randomized Controlled Trial |
| Actual Study Start Date : | 2021-02-10 |
| Estimated Primary Completion Date : | 2027-02 |
| Estimated Study Completion Date : | 2027-03 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Helsinki University Hospital
Helsinki, Finland,
RECRUITING
Kuopio University Hospital
Kuopio, Finland,
NOT YET RECRUITING
Oulu University Hospital
Oulu, Finland,
RECRUITING
Tampere University Hospital
Tampere, Finland,
NOT YET RECRUITING
Turku University Hospital
Turku, Finland,
RECRUITING
Oslo University Hospital
Oslo, Norway,
RECRUITING
University Hospital of North Norway
Tromsø, Norway,