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NCT04725292 | Completed | Skin Diseases

Rare Benign Lesion of Peins

Assiut University

Information provided by (Responsible Party):

Abdelrahman Mohamed Abdelkader

Brief Summary:

PEKMB was first named and described by Lortat-Jacob & Civatte in 1961 and by Bart & Kopf later. This rare condition is mostly reported in elderly males. The keratotic scales is usually micaceous and resembles psoriasis. Most patients are above 50 years of age and are circumcised later in life, but also reported in younger age group. This mica like scales contains keratin which gets dissolved in 10% potassium hydroxide solution. Disease progression may lead to phimosis. Differential diagnosis of this disease entity include moniliasis, wart, psoriasis ,penile horn, circinate balanitis, erythroplasia of Queyrat, squamous cell epithelioma and verrucous carcinoma. It is primarily a benign entity, it is capable of invasiveness. Bart and Kopf considered it to be in intermediate stage between benign hyperplasia and squamous cell carcinoma. However, the histological spectrum can range from hypertrophic-hyperplastic penile dystrophy to verrucous carcinoma. Fibro sarcoma has been reported developing in a same patient. Etiology is unclear. Despite search for a viral agent, Human Papilloma Virus (HPV) has not been demonstrated and its role in pathogenesis or its transformation to verrucous carcinoma has been proved. The treatment of PEKMB should be conservative when there is no histological evidence of malignancy. All such patients should be followed up. Treatment choices include potent topical steroids, topical 5% 5-flurouracil cream1, 2, cryotherapy, radiotherapy and shaving biopsy plus electro coagulation. When frank malignancy is observed, excision with wide margin is the rule.

Condition or disease

Skin Diseases

Penile Diseases

Study Type : Observational
Estimated Enrollment : 1 participants
Official Title: Pseudoepitheliomatous Hyperplasia of the Penis a Very Rare Disease in Egypt
Actual Study Start Date : January 12, 2021
Estimated Primary Completion Date : January 12, 2021
Estimated Study Completion Date : January 12, 2021

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 35 Years to 50 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Inclusion Criteria
  • 40 years
  • failed medical treatment
Exclusion Criteria
  • psoriasis
  • allergy
  • trauma

Rare Benign Lesion of Peins

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Rare Benign Lesion of Peins

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Egypt, Assuit

Assuit Medical School

Assiut, Assuit, Egypt, 71621